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FLASH GENE

Symbol

DCPS

contributors: mct - updated : 15-05-2019

HGNC name	decapping enzyme, scavenger
HGNC id	29812

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ARQS Al-Raqad syndrome
Location	11q24.2      Physical location : 126.173.646 - 126.215.643
Synonym name	heat shock-like protein 1
	histidine triad protein member 5
	homolog of C. elegans 7meGMP-directed hydrolase dcs-1
	mRNA decapping enzyme
Synonym symbol(s)	HSL1, HINT-5, HSPC015, ARS, DCS1, HINT5
EC.number	3.6.1.59

DNA

TYPE	functioning gene
STRUCTURE	46.25 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001350236 6 - 5773 NP_001337165 - 344 - 2015 26584588 NM_014026 6 - 5752 NP_054745 - 337 - 2015 26584588

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Reproductive female system placenta         male system testis         male system prostate       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	umbilical cord blood

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a domain-swapped N- terminus
	a histidine triad (HIT) sequence

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to rattus Dcps

Homologene

FAMILY

HIT family of pyrophosphatases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML

basic FUNCTION	catalyzes residual cap hydrolysis following mRNA degradation, releasing N-7 methylguanosine monophosphate and 5'diphosphate terminated cap or mRNA products
	can modulate pre-mRNA splicing
	is a multifunctional protein initially identified by its property to hydrolyze the resulting cap structure following 3prime end mRNA decay
	is a nucleocytoplasmic shuttling protein that activates miRNA degradation independently of its scavenger decapping activity in the cytoplasmic compartment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forming an assymetric homodimer

INTERACTION

DNA

RNA

binding

small molecule

protein	interacting with the 3' to 5' exonuclease exosome components
	DCPS in conjunction with XRN1 has the potential to regulate RNA stability in a transcript-selective manner in mammalian cells
	new function for DCPS requires the contribution of the 5prime-3prime exonuclease XRN2
	Natural antisense transcript (NATTD) is a regulator of DCPS transcription through epigenetic mechanisms

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARQS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS