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FLASH GENE
Symbol DCP2 contributors: mct - updated : 17-05-2017
HGNC name DCP2 decapping enzyme homolog (S. cerevisiae)
HGNC id 24452
Location 5q22.2      Physical location : 112.312.432 - 112.356.666
Synonym name
  • nudix (nucleoside diphosphate linked moiety X)-type motif 20
  • DCP2 decapping enzyme
  • nucleoside diphosphate-linked moiety X motif 20
  • mRNA-decapping enzyme 2
    • Synonym symbol(s) FLJ33245, NUDT20
    EC.number 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 44.24 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8947 48.3 420 - 2008 18039849
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NUDIX domain
    • HOMOLOGY
    interspecies homolog to rattus LOC291604
    Homologene
    FAMILY
  • Nudix hydrolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,nucleus
    text polysomes
    basic FUNCTION
  • catalytically active mRNA decapping enzyme
  • generating m7GDP and 5'-phosphorylated mRNAs (with a higher activity towards mRNAs lacking a polyA tail)
  • necessary for the degradation of mRNAs, both in normal turn-over and in nonsense-mediated mRNA decay
  • can specifically bind to and regulate the stability of a subset of mRNAs, and its intriguing regulation of the 3'-to-5' exonuclease exosome subunit suggests a potential interplay between 5'-end mRNA decapping and 3'-end mRNA decay
  • RNA binding protein that must bind RNA in order to recognize the cap for hydrolysis
  • six Nudix proteins as well as both DCP2 and NUDT16 could hydrolyze the cap of an unmethylated capped RNA, indicating that decapping enzymes may be less constrained for the presence of the methyl moiety
  • multiple Nudix family hydrolases may function in mRNA decapping and mRNA stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
    • INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • ion Mn2+ binding
  • can also use ion Mg2+
    • protein
  • interacting with the nonsense-mediated decay factor RENT1
  • also interacting with DCP1A, DCP1B, UPF2, UPF3B
  • important subunits of PBs (processing bodies) and is activated on AU-rich element-mRNAs by the protein ZFP36
  • EDC3 binding to DCP2 is mediated by a short peptide sequence located C terminal to the catalytic domain of DCP2
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS