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FLASH GENE
Symbol DCP2 contributors: mct - updated : 17-05-2017
HGNC name DCP2 decapping enzyme homolog (S. cerevisiae)
HGNC id 24452
Location 5q22.2      Physical location : 112.312.432 - 112.356.666
Synonym name
  • nudix (nucleoside diphosphate linked moiety X)-type motif 20
  • DCP2 decapping enzyme
  • nucleoside diphosphate-linked moiety X motif 20
  • mRNA-decapping enzyme 2
    • Synonym symbol(s) FLJ33245, NUDT20
    EC.number 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 44.24 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC255338 5q22.1 hypothetical LOC255338 LOC91137 5q22.2 hypothetical protein BC017169 LOC134433 5q22.2 similar to Zinc finger DHHC domain containing protein 8 (Zinc finger protein 378) LOC285639 5q22.2 similar to Bcl-2-associated transcription factor TSLP 5q22.2 thymic stromal lymphopoietin TA-WDRP 5q22.2 T-cell activation WD repeat protein LOC133744 5q22.2 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 CAMK4 5q21-q23 calcium/calmodulin-dependent protein kinase IV STARD4 5q21.3 START domain containing 4, sterol regulated C5orf13 5q22.1 chromosome 5 open reading frame 13 TIGA1 5q21-q22 TIGA1 EPB41L4A 5q22.1 erythrocyte membrane protein band 4.1 like 4A FLJ11235 5q22.2 hypothetical protein FLJ11235 APC 5q21-q22 adenomatosis polyposis coli SRP19 5q21 signal recognition particle 19kDa DP1 5q22-q23 polyposis locus protein 1 XBPP1 5q14.3-q15 X-box binding protein pseudogene 1 U2AF1L1 5q22 U2(RNU2) small nuclear RNA auxillary factor 1-like 1 DCP2 5q22.3 decapping enzyme hDcp2 MCC 5q21 mutated in colorectal cancers STK22D 5q22.2 serine/threonine kinase 22D (spermiogenesis associated) LOC389316 5 LOC389316 FLJ21940 5q22.3 FLJ21940 protein KCNN2 5q22.3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 TRIM36 5q22 tripartite motif-containing 36 PGGT1B 5q23.1 protein geranylgeranyltransferase type I, beta subunit MGC39633 5q23.1 hypothetical protein MGC39633 CTNNAP1 5q22 catenin (cadherin-associated protein), alpha pseudogene 1 LOC340068 5q23.1 similar to T-complex protein 1, epsilon subunit (TCP-1-epsilon) (CCT-epsilon) FEM1C 5q22-q23.1 fem-1 homolog c (C.elegans)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 8947 48.3 420 - 2008 18039849
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     thymus   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a NUDIX domain
    • HOMOLOGY
    interspecies homolog to rattus LOC291604
    Homologene
    FAMILY
  • Nudix hydrolase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,nucleus
    text polysomes
    basic FUNCTION
  • catalytically active mRNA decapping enzyme
  • generating m7GDP and 5'-phosphorylated mRNAs (with a higher activity towards mRNAs lacking a polyA tail)
  • necessary for the degradation of mRNAs, both in normal turn-over and in nonsense-mediated mRNA decay
  • can specifically bind to and regulate the stability of a subset of mRNAs, and its intriguing regulation of the 3'-to-5' exonuclease exosome subunit suggests a potential interplay between 5'-end mRNA decapping and 3'-end mRNA decay
  • RNA binding protein that must bind RNA in order to recognize the cap for hydrolysis
  • six Nudix proteins as well as both DCP2 and NUDT16 could hydrolyze the cap of an unmethylated capped RNA, indicating that decapping enzymes may be less constrained for the presence of the methyl moiety
  • multiple Nudix family hydrolases may function in mRNA decapping and mRNA stability
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
    • INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • ion Mn2+ binding
  • can also use ion Mg2+
    • protein
  • interacting with the nonsense-mediated decay factor RENT1
  • also interacting with DCP1A, DCP1B, UPF2, UPF3B
  • important subunits of PBs (processing bodies) and is activated on AU-rich element-mRNAs by the protein ZFP36
  • EDC3 binding to DCP2 is mediated by a short peptide sequence located C terminal to the catalytic domain of DCP2
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS