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FLASH GENE
Symbol DCP1A contributors: mct - updated : 21-03-2009
HGNC name DCP1 decapping enzyme homolog A (S. cerevisiae)
HGNC id 18714
Location 3p21.1      Physical location : 53.317.446 - 53.381.654
Synonym name
  • transcription factor SMIF
  • decapping enzyme
  • Smad4-interacting transcriptional co-activator
  • putative protein product of Nbla00360
    • Synonym symbol(s) SMIF, HSA275986, SMAD4IP1, FLJ21691, Nbla00360
    EC.number 3.-.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 64.21 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6025 63.2 582 - 2006 17081983
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemovary   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text umbilical cord blood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Dcpa1
    Homologene
    FAMILY
  • DCP1 family
    • CATEGORY signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text found in P-bodies and functions in mRNA cap removal prior to its degradation
    basic FUNCTION
  • may be recruited to mRNAs containing premature termination codons
  • participating in the TGF-beta signaling pathway
  • function influenced by post-translational modification in response to various physiological cues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • key component in the processes of mRNA decapping and degradation
  • part of a signaling pathway, which is activated during neuronal and brain development
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SMAD4 and acts as a transcription co-activator in the transforming growth factor beta (TGFB) pathway)
  • interacting with DCP2 and DCP1B
  • important subunits of PBs (processing bodies) and is activated on AU-rich element-mRNAs by the protein ZFP36
  • PATL1 interacting with DCP2/DCP1A, LSM1/LSM4, EDC4, and EDC3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS