| basic FUNCTION
| nuclease required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments |
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required for the maintenance of a normal DNA damage-induced G2/M cell cycle arrest |
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required to cleave DNA hairpins at coding joints during V(D)J recombination, for repair of DSBs by the non homologous end joining pathway, and for cell cycle checkpoint regulation in response to DNA damage  |
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involved in V(D)J recombination and nonhomologous end joining (NHEJ) of DNA double-strand break (DSB) repair |
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but only partially participates in the NHEJ pathway to repair DSBs in human somatic cells |
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negative regulator of TP53 in response to oxidative stress in both primary cells and cancer cell lines |
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DNA nuclease that plays important roles in non-homologous end-joining (NHEJ), a major double-strand break (DSB) repair pathway |
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is involved in multiple biological processes through interactions with different binding partners |
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while both SETMAR and DCLRE1C are biochemically capable of resolving a variety of damaged DNA ends for the repair of complex double-strand breaks, DCLRE1C appears to act more efficiently in the context of other nonhomologous end joining proteins |
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is the major downstream effector of the TP53BP1 pathway, which prevents end resection and promotes nonhomologous end-joining and therefore directly competes with the homologous recombination repair pathway |
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DCLRE1C and ERCC4-ERCC1 can also induce stalled DNA replication forks cleavage through non-epistatic pathways all along S and G2 phases of the cell cycle |
