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FLASH GENE
Symbol DCLK3 contributors: mct/npt - updated : 04-05-2010
HGNC name doublecortin-like kinase 3
HGNC id 19005
Location 3p22.2      Physical location : 36.753.912 - 36.781.352
Synonym name
  • doublecortin and CaM kinase-like 3
  • serine/threonine-protein kinase DCLK3
  • click-related protein
  • Synonym symbol(s) KIAA1765, DCDC3C, DCAMKL3, CLR
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 27.44 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 5344 73 648 - Reiner (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine/threonine protein kinases
  • catalytic domain
  • only possessed a partial and dysfunctional Dx domain (doublecortin-like domain)(Ohmae 2006)
  • HOMOLOGY
    interspecies ortholog to murine Dcamkl3
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in a calcium-signaling pathway controlling neuronal migration in the developing brain
  • may also participate in functions of the mature nervous system
  • involved in invasion, and aggressiveness of prolactin pituitary tumors (Wierinckx 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS