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FLASH GENE
Symbol DCLK2 contributors: mct/npt - updated : 05-05-2010
HGNC name doublecortin-like kinase 2
HGNC id 19002
Location 4q31.3      Physical location : 150.999.425 - 151.178.606
Synonym name
  • serine/threonine-protein kinase DCAMKL2
  • doublecortin kinase-2
  • serine/threonine-protein kinase DCLK2
  • doublecortin and CaM kinase-like 2
  • Synonym symbol(s) MGC45428, DCDC3, DCK2, DKFZp761I032, DCAMKL2, DCDC3B
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 178.53 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 3611 - 766 expressed predominantly in fetal brain Edelman (2005)
    16 - 3608 - 765 abundantly in both fetal and adult brain Edelman (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrainlimbic systemhippocampus highly
     nervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text
  • brain, detectable in lung and liver, but not in kidney
  • coexpressed in developing hippocampus with DCX (Kerjan 2009)
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two doublecortin domains
  • a protein kinase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain
  • may also participate in functions of the mature nervous system
  • having microtubule binding activity associated with its doublecortin domain and protein kinase activity mediated by a kinase domain, organized in a structure in which the two domains are functionally independent
  • represent a phosphorylation-dependent switch for the reversible control of microtubule dynamics in the vicinity of neuronal growth cones
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS