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FLASH GENE

Symbol

DCLK1

contributors: mct/npt - updated : 03/01/2009

HGNC name	doublecortin-like kinase 1
HGNC id	2700

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	13q13      Physical location : 36.342.789 - 36.705.514
Synonym name	doublecortin-like kinase
	doublecortin and CaM kinase-like 1
	serine/threonine-protein kinase DCLK1
Synonym symbol(s)	KIAA0369, DCLK, DCAMKL1, DCDC3A
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	360.00 kb     18 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D13S220 - D13S1197 - D13S805 - DCLK1 - D13S1164 - D13S1174 - D13S1159 - D13S219 - qter
Authors	Sossey-Alaoui (99)

RNA

TRANSCRIPTS	type	messenger

text	type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain an alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 - A long - splicing - 82.2 740 - Omori variant 1 - A short 18 splicing 8082 81 729 - Matsumoto, Omori, Kim (2003) variant 4 - B long - splicing - 47.6 433 adult, fetal brain Omori variant 3 - B short - splicing - - 422 - Omori

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon       liver         Endocrine neuroendocrine pituitary     predominantly Hearing/Equilibrium ear inner     highly Homo sapiens Lymphoid/Immune spleen       moderately   thymus         Nervous brain       moderately   nerve       moderately Reproductive female system ovary         male system prostate         male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     moderately Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain, lung, liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N terminal region homologous to DCX (doublecortin) and to a rat Ca2+/calmodulin dependent kinase CPG16 at C terminus
	two doublecortin domains

HOMOLOGY

interspecies

ortholog to murine Dcamkl1 (98.4pc)

intraspecies

homolog to calcium/calmodulin-dependent protein kinase 1

Homologene

FAMILY	Ser/Thr protein kinase family
	CaMK subfamily

CATEGORY

signaling , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	localized in mitotic cells, radial glial cells and radial processes

basic FUNCTION	participating in functions of the mature nervous system
	involved in a calcium-signaling pathway controlling neuronal migration in the developing brain
	acting as a protein serine/threonine kinase
	acting as a receptor signaling protein
	may have a role in migrating neurons
	critically involved in dynamic rearrangement of the cytoskeletal machinery that allow migration
	playing a unique role in mitotic spindle integrity during early neurogenesis in radial glial cell proliferation and their radial process stability

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development , nervous system , cellular trafficking transport

text	central nervous system development
	endosome transport

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

DCX to form a potentially mutually regulatory network linking calcium signaling and microtubule dynamics

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS