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FLASH GENE
Symbol DCLK1 contributors: mct/npt - updated : 03/01/2009
HGNC name doublecortin-like kinase 1
HGNC id 2700
Location 13q13      Physical location : 36.342.789 - 36.705.514
Synonym name
  • doublecortin-like kinase
  • doublecortin and CaM kinase-like 1
  • serine/threonine-protein kinase DCLK1
  • Synonym symbol(s) KIAA0369, DCLK, DCAMKL1, DCDC3A
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 360.00 kb     18 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen - D13S220 - D13S1197 - D13S805 - DCLK1 - D13S1164 - D13S1174 - D13S1159 - D13S219 - qter
    Authors Sossey-Alaoui (99)
    RNA
    TRANSCRIPTS type messenger
    text
  • type A (AS and AL) and type B (BS and BL) isoforms differ respectively by the presence or absence of the doublecortin domain
  • an alternative splicing occurring in 3' of the mRNA produces the long (L) instead of the short (S) isoforms
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing - 82.2 740 - Omori
    18 splicing 8082 81 729 - Matsumoto, Omori, Kim (2003)
    - splicing - 47.6 433 adult, fetal brain Omori
    - splicing - - 422 - Omori
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
    Endocrineneuroendocrinepituitary  predominantly
    Hearing/Equilibriumearinner  highly Homo sapiens
    Lymphoid/Immunespleen   moderately
     thymus    
    Nervousbrain   moderately
     nerve   moderately
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, lung, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N terminal region homologous to DCX (doublecortin) and to a rat Ca2+/calmodulin dependent kinase CPG16 at C terminus
  • two doublecortin domains
  • HOMOLOGY
    interspecies ortholog to murine Dcamkl1 (98.4pc)
    intraspecies homolog to calcium/calmodulin-dependent protein kinase 1
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text localized in mitotic cells, radial glial cells and radial processes
    basic FUNCTION
  • participating in functions of the mature nervous system
  • involved in a calcium-signaling pathway controlling neuronal migration in the developing brain
  • acting as a protein serine/threonine kinase
  • acting as a receptor signaling protein
  • may have a role in migrating neurons
  • critically involved in dynamic rearrangement of the cytoskeletal machinery that allow migration
  • playing a unique role in mitotic spindle integrity during early neurogenesis in radial glial cell proliferation and their radial process stability
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development , nervous system , cellular trafficking transport
    text
  • central nervous system development
  • endosome transport
  • PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • DCX to form a potentially mutually regulatory network linking calcium signaling and microtubule dynamics
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS