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FLASH GENE
Symbol DCK contributors: mct - updated : 29-03-2008
HGNC name deoxycytidine kinase
HGNC id 2704
Location 4q13.1-q21.1      Physical location : 71.859.264 - 71.896.627
Synonym symbol(s) MGC117410, MGC138632
EC.number 2.7.1.74
DNA
TYPE functioning gene
STRUCTURE 37.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2460 30.5 260 - Lamba (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   highly
 thymus   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a nuclear localization signal (NLS)
mono polymer homomer , dimer
HOMOLOGY
Homologene
FAMILY DCK/DGK family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • catalyzes the rate-limiting step of the deoxyribonucleoside salvage pathway in cells and plays a key role in the activation of numerous nucleoside analogues used in anti-cancer and antiviral chemotherapy
  • rate-limiting enzyme in the activation of nucleoside analogs such as cytarabine (ara-C), gemcitabine, clofarabine, and others
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by phosphorylation on Ser-74
    Other reversibly phosphorylated in normal human lymphocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    overexpression associated with risk of intoxication by cytotoxic nucleoside derivalues
    tumoral     --low  
    deficiency associated with resistance to antiviral and anticancer chemotheropentic agents
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS