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FLASH GENE
Symbol DCBLD2 contributors: mct/npt - updated : 15-06-2009
HGNC name discoidin, CUB and LCCL domain containing 2
HGNC id 24627
Location 3q12.1      Physical location : 98.514.814 - 98.620.533
Synonym name
  • coagulation factor V/VIII-homology domains protein 1
  • endothelial and smooth muscle cell-derived neuropilin-like protein
  • CUB, LCCL and coagulation factor V/VIII-homology domains
  • protein 1
    Synonym symbol(s) CLCP1, ESDN, 1700055P21Rik
    DNA
    TYPE functioning gene
    STRUCTURE 105.72 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located mapped between D3S1552 and D3S1271
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 6093 85 775 - Sadeghi (2007)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
    Endocrinepancreas   moderately
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one CUB domain
  • a coagulation factor V/VIII homology domain
  • an LCCL domain
  • one MAM domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Esdn-pending
    homolog to rattus Esdn
    Homologene
    FAMILY
  • neuropilin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • playing a role in regulation of vascular cell growth
  • may have a wide variety of functions in other tissues including the nervous system like neuropilins
  • plays a role in cell motility, whereas they also showed that at least one of its ligands is SEMA4B and that their interaction mediates proteasome degradation by DCBLD2 (Nagai 2007)
  • marker of vascular remodeling and regulator of vascular smooth muscle cell proliferation (Sadeghi 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SEMA4B (regulation of DCBLD2 protein by ubiquitination and proteasome degradation enhanced in the presence of SEMA4B)(Nagai 2007)
  • cell & other
    REGULATION
    induced by in platelet-derived growth factor-BB-stimulated vascular smooth muscle cells in vitro and neointima of the balloon-injured carotid artery in vivo
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in metastatic lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • may become a target of therapy to inhibit metastasis of lung cancers (Nagai 2007)
  • may serve as a therapeutic or diagnostic target for graft arteriosclerosis (Sadeghi 2007)
  • ANIMAL & CELL MODELS