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FLASH GENE
Symbol DCAF7 contributors: mct - updated : 14-04-2015
HGNC name DDB1 and CUL4 associated factor 7
HGNC id 30915
Location 17q23.3      Physical location : 61.627.821 - 61.671.639
Genatlas name anthocyanin
Synonym name
  • WD-repeat protein
  • WD repeat-containing protein An11 homolog
  • WD repeat domain 68
  • seven-WD-repeat protein of the AN11 family-1
  • Synonym symbol(s) AN11, HAN11, WDR68, SWAN-1
    DNA
    TYPE functioning gene
    STRUCTURE 43.82 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6369 38 342 - 2010 20940704
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four WD repeats
  • HOMOLOGY
    interspecies ortholog to petunia An11
    ortholog to C. Elegans Swan-1 and Swan-2
    Homologene
    FAMILY
  • WD repeat WDR68 family
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • the binding of DYRK1A, but not the phosphorylation event, induces the nuclear translocation of DCAF7 5)
  • basic FUNCTION
  • involved in signal transduction
  • required to allow coupling of MAP3K1 to DYRK1A and HIPK2
  • novel scaffold protein regulating kinase signalling by HIPK2 and MAP3K1
  • functions as a scaffold protein with the ability to directly bind HIPK2, MAP3K1 and DYRK1A/DYRK1B
  • essential role for cell proliferation and the osmotic stress response
  • role in the regulation of MAPK-dependent signalling events, and can function as a bridging protein that allows coupling of MAP3K1-dependent effects on HIPK2
  • scaffolding protein required for craniofacial development and left-right asymmetry
  • nuclear role for DCAF7-containing complexes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may be a physiological regulator of GLI1 transcriptional activity
  • interactor of the kinase homeodomain-interacting protein kinase 2 (HIPK2)
  • DYRK1A, DYRK1B, bind to the evolutionary conserved DCAF7 protein
  • DYRK1A binds specifically to DCAF7 in cells, and the binding, but not the phosphorylation event, induces the nuclear translocation of DCAF7 5)
  • binds to several proteins, including dual specificity tyrosine phosphorylation-regulated protein kinase (DYRK1A), MAPK/ERK kinase kinase 1 (MEKK1), and Cullin4-damage-specific DNA-binding protein 1 (CUL4-DDB1)
  • TCP1 ring complex/chaperonin-containing TCP1 (TRiC/CCT) were identified as major DCAF7-binding proteins, and phosphorylation sites in both DCAF7 and TRiC/CCT were identified
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS