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FLASH GENE
Symbol DBX1 contributors: mct - updated : 25-05-2022
HGNC name developing brain homeobox 1
HGNC id 33185
Location 11p15.1      Physical location : 20.177.759 - 20.181.870
Synonym name homeobox protein DBX1
DNA
TYPE functioning gene
STRUCTURE 4.32 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1242 - 343 - 2001 11239429
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
  • HOMOLOGY
    interspecies homolog to rattus Dbx1 (91 pc)
    homolog to murine Dbx1 (89.9 pc)
    Homologene
    FAMILY
  • H2.0 homeobox family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing a role in patterning the central nervous system during embryogenesis
  • playing a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons
  • regulating the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons
  • DBX1-expressing cells have a unique function during head development, notably by controlling cell survival in a non cell-autonomous manner
  • has an essential function in assigning midline-crossing identity, thereby contributing crucially to the establishment of the wiring laterality in the developing nervous system
  • DBX1, is a shared requirement for the specification of hypothalamic nuclei governing a subset of innate behaviors
  • in a temporally regulated manner, DBX1-derived neurons contribute to molecularly distinct neuronal populations in the LH, Arc and VMH that have been implicated in a variety of hypothalamic-driven behaviors
  • enrichment of DBX1-lineage neurons in the ventral anterior piriform cortex (PC)that project to the orbitofrontal cortex
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • DBX1 is a direct SOX3 target gene whose expression, intriguingly, is not fully rescued by other SOX transcription factors
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Dbx1 hypothalamic-specific conditional-knockout mice display attenuated responses to predator odor and feeding stressors but do not display deficits in other innate behaviors such as mating or conspecific aggression