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FLASH GENE
Symbol DBP contributors: mct - updated : 09-05-2012
HGNC name D site of albumin promoter (albumin D-box) binding protein
HGNC id 2697
Location 19q13.33      Physical location : 49.133.817 - 49.140.639
Synonym name vitamin D-binding protein
Synonym symbol(s) DABP
DNA
TYPE functioning gene
STRUCTURE 6.82 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - CEBPA - MAG - DBP - LHB LHB - KLK1 - qter
Authors Stubbs (96)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1658 - 325 - 1999 10364202
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbraindiencephalonhypothalamussuprachiasmatic nuclei 
 nerve   highly
Urinarykidney    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic region, leucine zipper, proline and acidic aminoacids rich
  • a DAGKC domain
  • mono polymer aggregate
    HOMOLOGY
    Homologene
    FAMILY PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate, a lipid mediator with both intra- and extracellular function
  • preventing loss of 25(OH)D3
  • release of DBP at sites of endothelial injury represents a novel pathway favoring accumulation of vascular smooth muscle cells at sites of vascular injury
  • multifunctional transport protein with a decreased serum concentration in cystic fibrosis (CF)
  • important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone, but the binding protein)does not influence the hormone biologically active pool
  • role of vitamin D binding protein in multiple sclerosis
  • DBP and NFIL3 proteins are critical for determining the period length of the circadian oscillator
  • association between vitamin D homeostasis and intestinal inflammation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism metal , vitamin
    signaling
    modulating important clock output genes
    a component with 25(OH)D3
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • to calmodulin
  • binds to and transports vitamin D to target tissues to maintain calcium homeostasis through the vitamin D endocrine system
  • modifies the vitamin D-bone mineral density relationship
  • ARNTL and CLOCK may act as Kamikaze activators, in that they are rapidly degraded once bound to DBP chromatin
  • cell & other
    REGULATION
    Other strong circadian rhythmicity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    Decreased serum DBP concentrations were observed in the CF
    Susceptibility
  • to inflammatory bowel disease
  • to chronic obstructive pulmonary disease
  • Variant & Polymorphism other
  • inverse association between the DBP 420 Lys and inflammatory bowel disease
  • association of DBP variants with susceptibility to chronic obstructive pulmonary disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS