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FLASH GENE
Symbol DBN1 contributors: mct/npt - updated : 25-01-2012
HGNC name drebrin 1
HGNC id 2695
Location 5q35.3      Physical location : 176.883.613 - 176.900.694
Synonym name
  • developmentally-regulated brain protein
  • drebrin E2
  • drebrin E
  • Synonym symbol(s) DRE, D0S117E, DKFZp434D064
    DNA
    TYPE functioning gene
    STRUCTURE 17.08 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure several NXF/Arnt binding elements on the promoter, which could be direct or indirect cross talking points between NXF (activation) and Sim2 (repression) action
    MAPPING cloned Y linked N status confirmed
    Physical map
    KIAA1893 5q35.3 G protein-regulated inducer of neurite outgrowth 1 SNCB 5q35 synuclein, beta LOC253314 5q35.3 similar to eukaryotic translation initiation factor eIF4E-1 MGC14859 5q35.3 hypothetical protein MGC14859 LOC389348 5 LOC389348 KIAA1976 5q35.3 netrin receptor Unc5h1 HK3 5q35.2-q35.3 hexokinase 3 (white cell) RAP80 5q35.3 receptor associated protein 80 JAZ 5q35.3 double-stranded RNA-binding zinc finger protein JAZ FGFR4 5q35.3 fibroblast growth factor receptor 4 NSD1 5q35.1-q35.3 nuclear receptor binding SET domain protein 1 RAB24 5q35.3 RAB24, member RAS oncogene family PX19 5q35.3 px19-like protein MXD3 5q35.3 MAX dimerization protein 3 LMAN2 5q35 lectin, mannose-binding 2 RGS14 5q35.3 regulator of G-protein signalling 14 SLC34A1 5q35.1 solute carrier family 34 (sodium phosphate), member 1 LOC345456 5q35.3 similar to profilin 3 F12 5q35.1 coagulation factor XII (Hageman factor) GPRK6 5q35 G protein-coupled receptor kinase 6 MGC10772 5q35.3 hypothetical protein MGC10772 DBN1 5q35.3 drebrin 1 FLJ22570 5q35.3 Dok-like protein DDX41 5q35.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 HSGP25L2G 5q35.3 gp25L2 protein LOC391854 5 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) ENIGMA 5q34-q35 similar to Beta-1,4-galactosyltransferase 7 (Beta-1,4-GalTase 7) (Beta4Gal-T7) (b4Gal-T7) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7) FLJ10404 5q35.3 hypothetical protein FLJ10404 B4GALT7 5q35.2-q35.3 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I) LOC202181 5q35.3 hypothetical protein LOC202181 NY-REN-7 5q35.3 NY-REN-7 antigen LOC391855 5 similar to olfactory receptor MOR126-1 LOC389349 5 hypothetical gene supported by NM_032361 LOC285647 5q35.3 similar to FLJ00052 protein PROP1 5q11.2 prophet of Pit1, paired-like homeodomain transcription factor LOC389350 5 similar to KIAA0752 protein LOC285658 5q35.3 similar to 60S ribosomal protein L19
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2942 - 649 - 2010 21124928
  • DBN1 Ia
  • 15 splicing 3058 - 651 - 2010 21124928
  • DBN1 Ib
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Lymphoid/Immunethymus   moderately
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, fetal brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two domains in the N-terminal half, a coiled-coil domain and a helical domain-that independently bound to F-actin and cooperatively bundled F-actin (pMID: 23979715)
  • an actin-binding domain, which causes the same rearrangements in the cytoskeleton as the full-length protein
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • postsynaptic localization of drebrin depended on actin cytoskeleton organization in both GABAergic and glutamatergic neurons
  • basic FUNCTION
  • involved in neuronal growth
  • may be playing some role in cell migration, extension of neuronal processes and plasticity of dendrites
  • may be invoved in dendritic-cytoskeleton modulation at synapses
  • may affect spine dynamics, vesicle transport, and other myosin-V-driven motility in neurons through attenuating the interaction between actin and myosin-V
  • might regulate dendritic spine morphology via regulation of actin cytoskeleton remodeling and dynamics
  • plays an indispensable role in some processes of generating fear learning and memory
  • involved in the regulation of actin filament organisation, especially during the formation of neurites and cell protrusions of motile cells
  • filament-binding protein involved in organizing the dendritic pool of actin
  • actin filament (F-actin)-binding protein with crucial roles in neuritogenesis and synaptic plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin binding
  • interacting with NPAS4
  • targets MAPRE3 to coordinate F-actin–microtubule interactions that underlie neuritogenesis
  • decreased the Mg-ATPase activity of myosin V
  • interactions between DBN and RAS regulate dendritic spine plasticity
  • competition between drebrin and several other F-actin-binding proteins
  • DBN1, SETMAR, HILPDA, are direct targets of the SOX11 protein (are direct transcriptional targets of the SOX11 protein)
  • contains a cryptic F-actin-bundling activity regulated by CDK5 phosphorylation
  • cell & other
    REGULATION
    Other developmentally regulated
    regulated by SIM2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in frontal and temporal cortex in Alzheimer disease and trisomy 21
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS