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FLASH GENE
Symbol DBI contributors: mct/ - updated : 08-11-2006
HGNC name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
HGNC id 2690
Location 2q14.2      Physical location : 120.124.503 - 120.130.120
Synonym name
  • diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
  • endozepine
  • GABA receptor modulator
  • acyl-Coenzyme A binding domain containing 1
  • cholecystokinin-releasing peptide, trypsin-sensitive
    • Synonym symbol(s) ACBP, ACBD1, MGC70414
    EC.number 3.4.17.3
    DNA
    TYPE functioning gene
    STRUCTURE 5.62 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site   HRE
    text structure PPAR-response element (PPRE) in intron 1
    MAPPING cloned Y linked N status provisional
    Physical map
    DDX18 2q13 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 LOC389024 2 LOC389024 LOC343958 2q14.2 similar to 5-HT5B serotonin receptor FLJ10996 2q14.2 hypothetical protein FLJ10996 INSIG2 2q21.2 insulin induced gene 2 LOC389025 2 LOC389025 LOC151154 2q14.2 hypothetical LOC151154 EN1 2q14.2 engrailed homolog 1 MARCO 2q14.2 macrophage receptor with collagenous structure LOC165257 2q14.2 C1q-domain containing protein TSAP6 2q14.2 C1q-domain containing protein LOC389026 2 similar to PRO1546 DBI 2q12-q21 diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) PR1 2q14.2 voltage-dependent calcium channel gamma subunit-like protein SCTR 2q14.1 secretin receptor LOC200373 2q14.2 similar to hypothetical protein MGC10993 2q14.2 hypothetical protein MGC10993 PTPN4 2p24.3-p24.1 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) EPB41L5 2q21.2 erythrocyte membrane protein band 4.1 like 5 LOC391431 2 similar to NADH dehydrogenase subunit 5 FAM11B 2q21.2 similar to NADH dehydrogenase subunit 5 RALB 2cen-q13 v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) INHBB 2q12-q13 inhibin, beta B (activin AB beta polypeptide) FLJ14816 2q14.2 hypothetical protein FLJ14816 GLI2 2q24 GLI-Kruppel family member GLI2 TFCP2L1 2q14 transcription factor CP2-like 1 CLASP1 2q14-q21 cytoplasmic linker associated protein 1 MKI67IP 2q14.3 MKI67 (FHA domain) interacting nucleolar phosphoprotein TSN 2q21.1 translin LOC389027 2 LOC389027 LOC389028 2 LOC389028
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 708 11.66 104 - 2007 17044054
    4 splicing 616 9.9 87 - 2007 17044054
    also called 1a
    4 - 789 - 148 - -
    4 - 740 - 88 highly in adipose tissue 2007 17044054
  • also called 1c
  • specific regulation of this transcript by PPARgamma2
  • might be relevant for diseases like diabetes and obesity
    • 5 - 723 14.24 129 - -
    5 - 678 11.66 104 - -
    4 - 627 11.02 97 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Nervousbrain    
    Reproductivemale systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • an hydrophobic binding site for acylCoA esters located within the second helical region
  • an ACBP domain
    • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Dbi
    homolog to Drosophila tbh
    homolog to C.elegans H13N06.6
    Homologene
    FAMILY
  • ACBP family
    • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducing medium-chain acyl-CoA ester synthesis
  • intracellular lipid-binding protein that transports acylCoA esters
  • displacing diazepan from the benzodiazepine (BZD) recognition sites located on the GABA type A receptor (acting as a neuropeptide to modulate the action of the GABA receptor)
  • downregulating the effects of GABA
  • involved in lipid metabolism and regulated by hormones and feeding status via transcription factors such as sterol regulatory element-binding protein 1 and peroxisome proliferator-activated receptor-gamma (PPARgamma)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular carrier of acyl-CoA esters
    PATHWAY
    metabolism lipid/lipoprotein
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of (PPAR)gamma
  • sterol regulatory element-binding protein 1c (SREBP-1c) target gene in hepatocytes
    • cell & other
  • binding to medium and long-chain acylCoA esters
    • REGULATION
    induced by induced during adipocyte differentiation
    Other regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS