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FLASH GENE

Symbol

DARS

contributors: mct - updated : 10-09-2011

HGNC name	aspartyl-tRNA synthetase
HGNC id	2678

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q21.3      Physical location : 136.664.253 - 136.743.222
Synonym name	aspartyl-tRNA synthetase alpha 2
Synonym symbol(s)	YCR024C,nAspRS
EC.number	6.1.1.12

DNA

TYPE	functioning gene
STRUCTURE	78.97 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D2S2215 - D2S112 - D2S114 - MGAT5 - LCT LCT - D2S314 ,DARS - ACVR2A - D2S127 - D2S132 - qter
Authors	GeneMap (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001349 16 - 2322 - 501 - 2011 21121901

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       highly Lymphoid/Immune thymus       highly Nervous brain       highly Homo sapiens   brain forebrain cerebral cortex temporal cortex   Homo sapiens Fetal   brain forebrain cerebral cortex frontal cortex   Homo sapiens Fetal   brain limbic system hippocampus dentate gyrus   Mus musculus   brain hindbrain cerebellum     Mus musculus

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal alpha-helices showing amphiphilic characteristics with an extension involved in the transfer of Asp-tRNA to elongation factor alpha1 (EF1alpha)
	a region of conserved lysine residues which may be a nucleotide phosphate binding site

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

class-II aminoacyl-tRNA synthetase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
	intracellular,nuclear envelope
text	diffusely localized in cytoplasm and broadly expressed across tissue types, including the central nervous system

basic FUNCTION	charging its cognate tRNA with aspartate during protein biosynthesis
	catalyze the esterification of a specific amino acid

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

aminoacid

signaling

a component	component of an aminoacyl-tRNA synthetases complex
	core component of the translational machinery

INTERACTION

DNA

RNA

small molecule

protein	target of peptide nucleotide antibiotic Microcin C (

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS