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FLASH GENE
Symbol DAPK3 contributors: mct - updated : 30-01-2014
HGNC name death-associated protein kinase 3
HGNC id 2676
Location 19p13.3      Physical location : 3.958.451 - 3.969.826
Synonym name
  • ZIP kinase isoform
  • zipper-interacting protein kinase
  • DAP-like kinase
  • Synonym symbol(s) ZIP, ZIPK, FLJ36473, Dlk
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 11.38 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2105 52.5 454 - 2008 18515077
  • also called variant 1 or ZIPK-L
  • bind to myosin
  • play an important role in the regulation of myosin phosphorylation
  • - - 536 - 158 - 2006 17126281
  • also called ZIPK-S
  • C-terminal non-kinase domain containing a leucine zipper is eliminated
  • binds to myosin phosphatase targeting subunit 1(MYPT1) similar to the long isoform (ZIPK-L)
  • play an important role in the regulation of myosin phosphorylation
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal protein kinase domain
  • a conserved calmodulin binding domain
  • a basic leucine zipper at the C terminus required for dimerization and kinase activation, and possibly an autoinhibitory loop
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • DAP kinase subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text
  • presence of the T299 site of phosphorylation correlates with cytoplasmic localization
  • basic FUNCTION
  • inducing apoptosis
  • myosin-light chain kinase
  • transcriptional co-activator of the AR (interaction of ZIP kinase with AR seems to be mediated in part by apoptosis antagonizing transcription factor and in part by direct binding)
  • binding partner of activating transcription factor 4 (ATF4), a member of the activating transcription factor/cyclic AMP-responsive element-binding family of transcription factor proteins
  • plays a crucial role in androgen receptor-mediated transcription
  • implicated in cell death and transcriptional regulation
  • tumor suppresser gene, playing an important role in gastric cancer development through its pro-apoptotic function
  • may act as a cardiac regulatory light chain kinase and thereby affect contractility
  • Ca2+-independent kinase with various substrates participating in diverse processes, ranging from promotion of apoptosis, to attenuation of inflammatory signaling, to regulation of contraction in smooth muscle
  • with PPP1R14A, participate in the regulation of PRKCA and PRKCE on vascular calcium sensitivity after hemorrhagic shock
  • Ca(2+)-independent protein kinase that promotes myosin phosphorylation in both smooth muscle and non-muscle cells
  • tumor suppressor in which loss-of-function mutations promote increased cell survival, proliferation, cellular aggregation, and increased resistance to chemotherapy
  • may serve as a transcriptional regulator of canonical Wnt/beta-catenin signaling through interaction with NLK/TCF4
  • controls proliferation, migration, invasion, soft&
  • 8209;agar colony formation and tumor growth through activation of ERK/MYC signaling in A549 cells
    CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ATF4, a member of the ATF/CREB family
  • phosphorylating the regulatory light chain of myosin II in a Ca2+/calmodulin dependent manner
  • phosphorylates an immune disease-related IL6 signal transducer, STAT3, and regulates its activation
  • transcriptional co-activator of the AR (interaction of DAPK3 with AR seems to be mediated in part by apoptosis antagonizing transcription factor and in part by direct binding)
  • UBE2D3 is a DAPK3-binding partner (induced ubiquitination of DAPK3)
  • NLK is a DAPK3 -binding partner and DAPK3 regulates NLK-mediated repression of canonical Wnt/beta-catenin signaling
  • DAPK3 may be involved in the regulation of the cell cycle in human cells, by interacting with CDC14A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with tumor invasion, metastasis and poor prognosis in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may be a novel target for the treatment of non-small cell lung cancer (NSCLC)
    ANIMAL & CELL MODELS