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FLASH GENE
Symbol DAGLA contributors: mct/shn - updated : 29-09-2012
HGNC name diacylglycerol lipase, alpha
HGNC id 1165
Location 11q12.2      Physical location : 61.447.909 - 61.514.472
Synonym name
  • Sn1-specific diacylglycerol lipase alpha
  • chromosome 11 open reading frame 11
  • neural stem cell-derived dendrite regulator
  • Synonym symbol(s) KIAA0659, C11orf11, NSDDR, DAGLALPHA, DGL-alpha, DAGL(ALPHA)
    EC.number 3.1.1.34
    DNA
    TYPE functioning gene
    STRUCTURE 66.57 kb     20 Exon(s)
    regulatory sequence Binding site
    MAPPING cloned Y linked N status provisional
    Map pter - D11S1765 - D11S4076 - DALGA - D11S4205 - D11S1883 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 5761 115 1042 - - 14610053
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveintestine   lowly Homo sapiens
     stomach   lowly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemplacenta  lowly Homo sapiens
     male systemprostate  lowly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    NervousPurkinje cell Homo sapiens
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to Dagla, Mus musculus
    ortholog to Dagla, Rattus norvegicus
    ortholog to DAGLA, Pan troglodytes
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyzing the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), an endocannabinoid with an important role in retrograde trans-synaptic suppression of synaptic transmitter release
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text formation of the most prevalent endocannabinoid, 2-arachidonoylglycerol in the brain
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • fluorogenic and chromogenic substrates
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene for SCA20
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • endocannabinoid-mediated retrograde synaptic suppression was totally absent in the cerebellum, hippocampus, and striatum of DGLalpha knockout mice