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FLASH GENE
Symbol DACT3 contributors: mct - updated : 20-06-2012
HGNC name dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
HGNC id 30745
Location 19q13.32      Physical location : 47.150.869 - 47.164.395
Synonym name
  • arginine rich region 1
  • thymus expressed gene 3-like
  • Synonym symbol(s) MGC15476, RRR1, DPR3
    DNA
    TYPE functioning gene
    STRUCTURE 13.53 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2834 64.9 629 - 2008 18538736
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex highly Homo sapiens
    Reproductivefemale systemuterus    Mus musculusAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text in the ventral region of maturing somites, limb bud and branchial arch mesenchyme, and in the embryonic CNS mesenchyme
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • DACT (Dpr/Frodo) gene family
  • Dapper family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • negative regulator of Wnt/beta-catenin signaling
  • required for normal vertebrate development
  • negative regulator of Wnt/beta-catenin signaling that is transcriptionally repressed in colorectal cancer
  • DACT1 and DACT3 may contribute to early tooth formation by modulation of Wnt signaling pathways in the mesenchyme, including preodontoblasts
  • conserved role for DACT proteins in kinase-regulated biochemistry involving VANGLl and DVL
  • principal role for all DACT family members is in the Planar Cell Polarity pathway
  • antagonizes potentially the fibrotic actions of Wnt signaling in kidney
  • important role in unilateral ureteral obstruction-induced renal fibrosis by regulating the Wnt/b-catenin signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promoted DVL2 degradation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    transcriptionally repressed in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential strategy for therapeutic control of Wnt/beta-catenin signaling in colorectal cancer
    ANIMAL & CELL MODELS
  • adult Dapper3-/- mice exhibited a mild reduction in body weight compared with their wild-type littermates, suggesting a functional role of Dapper3 in postnatal growth