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FLASH GENE
Symbol DAAM1 contributors: mct/pgu - updated : 31-08-2016
HGNC name dishevelled associated activator of morphogenesis 1
HGNC id 18142
Location 14q23.1      Physical location : 59.655.398 - 59.836.471
Synonym name
  • cDNA sequence, expressed in brain, >100kDa, diaphanous homolog
  • Synonym symbol(s) KIAA0666, FLJ41657
    DNA
    TYPE functioning gene
    STRUCTURE 181.00 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 4256 - 1078 - 2010 20927366
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Respiratoryrespiratory tracttrachea  highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal GTPase binding domain (GBD) that encompasses the diaphanous inhibitory domain (DID)
  • FH1 domain
  • formin-homology-2 (FH2) domain
  • C-terminal diaphanous autoregulatory domain (DAD), and binding partner, DVL, that leads to the activation of DAAM1, and selectively inhibited endothelial cell proliferation
  • HOMOLOGY
    interspecies homolog to diaphanous
    Homologene
    FAMILY
  • FH protein subfamily implicated in cell polarity
  • formin protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • central player in mediating cytoskeletal reorganization and are epistatically positioned in a pathway downstream of Rho activation
  • directing nucleation and elongation of new actin filaments using its conserved formin-homology-2 (FH2) domain
  • DIAPH1 and DAAM1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases
  • regulates endothelial cell growth through microtubules stabilization in a cell type-selective manner
  • may be playing an unique role in endothelial cells not shared with other similar cell types
  • plays a key role in centrosome polarity
  • plays an important role in regulating the actin cytoskeleton via mediation of linear actin assembly
  • crucial role in regulating the actin cytoskeleton and tissue morphogenesis, and in heart morphogenesis
  • participates in noncanonical Wnt signaling during gastrulation
  • DIAPH2, DAAM1, FMNL1, and FMNL2 were found to be required for myofibrillogenesis, non-redundantly
  • DAAM1 and DAAM2 nucleate actin and mediate Wnt-induced cytoskeletal changes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to both DVL and Rho, and mediates Wnt-induced DVL-Rho complex formation
  • coexpression of DVL with DAAM1 leads to activation of DAAM1 as monitored by hyperactivation of the noncanonical WNT pathway
  • FLI1, a gelsolin family protein essential for early development, binds directly to DAAM1 and DIAPH1 (FLI1 enhances the intrinsic actin assembly activity of DAAM1 and DIAPH1 and is required for DAAM1-induced actin assembly in living cells)
  • DAAM1 likely has WNT5A-independent roles in cardiac development
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Daam1-deficient mice exhibit embryonic and neonatal lethality and suffer multiple cardiac defects, including ventricular noncompaction, double outlet right ventricles and ventricular septal defects
  • homozygous Daam1 conditional knockout (CKO) mice were viable but had misshapen hearts and poor cardiac function