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FLASH GENE
Symbol CYTH4 contributors: mct/npt - updated : 02-03-2009
HGNC name cytohesin 4
HGNC id 9505
Location 22q13.1      Physical location : 37.678.494 - 37.711.388
Synonym name
  • pleckstrin homology, Sec7 and coiled-coil domains 4
  • PH, SEC7 and coiled-coil domain-containing protein 4
  • Synonym symbol(s) PSCD4, CYT4, DJ63G5.1
    DNA
    TYPE functioning gene
    STRUCTURE 32.96 kb     13 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3138 45.5 394 - Beausoleil (2004)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
     thymus    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal coiled coil domain
  • a SEC7 domain promoting guanine-nucleotide exchange on ARF1
  • a C terminal pleckstrin homology (PH) domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to yeast Sec7
    intraspecies homolog to PSCD1
    Homologene
    FAMILY
  • pleckstrin SeC7 domain family
  • CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • a cytosolic guanine nucleotide-exchange protein for ADF-ribosylation factors ARF1, ARF5
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • phosphatidylinositol 3,4,5-triphosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS