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FLASH GENE
Symbol CYTH3 contributors: mct/npt/pgu - updated : 07-08-2012
HGNC name cytohesin 3
HGNC id 9504
Location 7p22.1      Physical location : 6.201.413 - 6.312.242
Synonym name
  • ARF nucleotide-binding site opener protein 3, cytohesin 3
  • pleckstrin homology, Sec7 and coiled-coil domains 3
  • general receptor of phosphoinositides 1
  • protein ARNO3
  • Synonym symbol(s) ARNO3 , GRP1, PSCD3
    DNA
    TYPE functioning gene
    STRUCTURE 110.83 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map pter - D7S1452 - D7S481 - CYTH3 - D7S3123 - D7S2139E - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 4482 46.2 399 - 2005 15878955
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal coiled coil motif, and heptad repeats which have also been shown to mediate homodimerization
  • a SEC7 domain promoting guanine-nucleotide exchange on ARF1
  • with a SEC7-pleckstrin homology (PH) domain tandem
  • a C terminal pleckstrin homology (PH) domain, involved in the membrane targeting and regulation, through multivalent mechanism
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to yeast Sec7
    homolog to rattus Pscd3
    Homologene
    FAMILY
  • phosphoinositide-dependent ARF GTPase exchange factors family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text translocated to the plasma membrane after activations
    basic FUNCTION
  • involved in the control of Golgi structure and function
  • may be having a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1
  • mediates the regulation of protein sorting and membrane trafficking
  • nucleotide exchange factor, which had never been shown to interact with nuclear receptors
  • corepressor for thyroid hormone receptors, which modulates both positive and negative regulation by T3 by decreasing thyroid hormone receptors-complex formation on response elements
  • cytohesin 2 is required for integrin beta1 recycling, whereas GRP1/cytohesin 3 is dispensable for this process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text mediating vesicle transport
    PATHWAY
    metabolism
    signaling
    a component formation of FERMD4B-CYTH3 heterodimer
    INTERACTION
    DNA
    RNA
    small molecule
  • receptor for phosphatidylinositol 3,4,5-triphosphate after stimulation by NGF or EGF
  • protein
  • interacting with CRTAP
  • active Arf6 also bound the PH domain of CYTH3
  • selectively binds phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P(3)], which is required for recruitment to the plasma membrane in stimulated cells
  • ^GRASP interacts with CYTH3, which catalyses nucleotide exchange on and activation of ARF6
  • cell & other
    REGULATION
    activated by PI (3,4,5) P3
    Other autoregulated by mechanisms that depend on plasma membrane recruitment for activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS