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FLASH GENE
Symbol CYTH1 contributors: mct/npt/pgu - updated : 17-03-2012
HGNC name cytohesin 1
HGNC id 9501
Location 17q25.3      Physical location : 76.670.130 - 76.778.376
Synonym name
  • cytoadhesin 1
  • homolog of secretory protein SEC7
  • pleckstrin homology, Sec7 and coiled/coil domains 1
  • SEC7 homolog B2-1
  • Synonym symbol(s) D17S811E, B2-1, SEC7, PSCD1, FLJ34050, FLJ41900
    DNA
    TYPE functioning gene
    STRUCTURE 108.25 kb     13 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D17S802 - D17S6137 - CYTH3 - D17S815E - D17S712 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3311 46.4 398 - 2003 12606567
    13 - 3308 46.3 397 - 2003 12606567
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal coiled coil domain
  • a central SEC7 domain promoting guanine-nucleotide exchange on ARF1
  • a C terminal pleckstrin homology (PH) domain
  • a 50-AA region (CIR domain) near the C terminus required for NEDD4L binding and for normal Sec7 localization
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to yeast Sec7
    Homologene
    FAMILY
  • PSCD family
  • Arf guanine nucleotide exchange factors (GEFs) family
  • CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text localized primarily to TGN membranes
    basic FUNCTION
  • a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor ARF1
  • intracellular guanine nucleotide exchange factor, which regulates leukocyte adhesion
  • linking growth factor stimulation of PI3-kinase to cell adhesion
  • Golgi-associated Arf GEF required for the formation of transport vesicles from the Trans-golgi network
  • CYTH1 and RHOA are both required for the induction of chemokine-dependent conformational changes of ITGB2 subunit of Dendritic cells during adhesion under physiological flow conditions
  • important component of ITGB2 activation in lymphocytes, and regulates the activation of the small GTPase RHOA in primary dendritic cells (DCs)
  • involvement in the regulation of the functional responses of polymorphonuclear neutrophils and these events are linked, in part at least, to the activation of ARF6
  • guanine nucleotide exchange factor for ADP ribosylation factor 6 (ARF6) in blood neutrophils
  • regulates adhesion and the transendothelial migration of monocytes, dendritic cells and T lymphocytes through activation of ITGB2
  • key regulator of neutrophil adhesion to endothelial cells and to components of extracellular matrix, which may influence cell emigration through its dual opposing effect on ITGB1, ITGB2 integrin activation
  • plays likely a role in transducing soluble ligand signals from neurons
  • ARF6 and CYTH1 are required for migration of primary Schwann cells
  • is required for Schwann cell migration, revealing a novel mechanism for Schwann cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text mediated vesicle transport
    PATHWAY
    metabolism
    signaling
    inside-outside
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacting with CD18 intracellular portion of integrin beta (ITGB2)
  • NEDD4L C2 domain-binding protein
  • interacting with CYTIP (upregulated by cytokines in hematopoietic cells and also recruited to the cell cortex by integrin signaling via its PDZ domain)
  • cell & other
    REGULATION
    Other activity of cytohesin-1 is controlled by phospho inositide-dependent membrane recruitment
    its actin cytoskeletal association is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS