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FLASH GENE
Symbol CYSLTR2 contributors: - updated : 14-02-2006
HGNC name cysteinyl leukotriene receptor 2
HGNC id 18274
Location 13q14.12-p21.1      Physical location : 49.280.950 - 49.283.498
Synonym symbol(s) CYSLT2, GPCR, HG57
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located located to a region linked to bronchial asthma
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Lymphoid/Immunelymph node    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments
conjugated GlycoP
HOMOLOGY
interspecies homolog to dog LOC485445
homolog to rattus Cysltr2
ortholog to murine Cysltr2
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • cysteinyl leukotrienes (C4,D4,E4) receptor
  • signaling through elevation of intracellular calcium
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by leukotrienes C4,D4,E4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS