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FLASH GENE
Symbol CYP51A1 contributors: mct - updated : 30-12-2015
HGNC name cytochrome P450, family 51, subfamily A, polypeptide 1
HGNC id 2649
Location 7q21.2-q21.3      Physical location : 91.741.463 - 91.764.059
Synonym name
  • sterol 14-alpha demethylase
  • cytochrome P450, 51 (lanosterol 14-alpha-demethylase)
  • lanosterol 14alpha-demethylase
  • Synonym symbol(s) P450DM, CYP51, CP51, CYPL1, LDM, P450-14DM, P450L1
    EC.number 1.14.14.1
    DNA
    TYPE like-sequence
    STRUCTURE 22.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    Binding site   cAMP   HRE
    text structure a cluster of regulatory elements including GC box,cAMP-responsive element CRE and sterol regulatory element SRE.(CRE binding site is essential for sterol regulation of the gene)
    MAPPING cloned Y linked N status confirmed
    Map cen - D7S492 - D7S2409 - (CYP51A1 - D7S1789 ) - D7S646 - D7S558 - D7S689 - D7S657 - D7S652 - CALCR - COL1A2 - qter
    Physical map
    STEAP2 7q21 six transmembrane epithelial antigen of prostate 2 FLJ21062 7q21.2 hypothetical protein FLJ21062 LOC85865 7q21.2 hypothetical protein BC004923 CLDN12 7q21 claudin 12 PFTK1 7q21-q13 PFTAIRE protein kinase 1 FZD1 7q21 frizzled homolog 1 (Drosophila) LOC389531 7 LOC389531 MTERF 7q21-q22 LOC389531 AKAP9 7q21-q22 a kinase (PRKA) anchor protein (yotiao) 9 CYP51A1 7q21.2-q21.3 cytochrome P450, family 51, subfamily A, polypeptide 1 LOC389532 7 similar to hypothetical protein 4932412H11 CCM1 7q21-q22 cerebral cavernous malformations 1 LOC392070 7 similar to RIKEN cDNA 4930500J03 LOC392071 7 similar to RIKEN cDNA 2810014D17 ODAG 7q21-q22 ocular development-associated gene PEX1 7q21-q22 peroxisome biogenesis factor 1 DKFZP564O0523 7q21.3 hypothetical protein DKFZp564O0523 MGC16142 7q21.3 hypothetical protein MGC16142 LOC392072 7 similar to hypothetical protein FLJ11767 MGC40405 7q21.3 hypothetical protein MGC40405 CDK6 7q21-q22 cyclin-dependent kinase 6 FLJ20073 7q21.3 FLJ20073 protein FLJ39885 7q21.3 hypothetical protein FLJ39885 LOC253012 7q21.3 hypothetical protein LOC253012 FLJ20097 7q21.3 hypothetical protein FLJ20097 CALCR 7q21.3 calcitonin receptor LOC346588 7q21.3 similar to Protein C6orf66 (HSPC125) (My013 protein) TFPI2 7q22 tissue factor pathway inhibitor 2 GNGT1 7q21.3 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 GNG11 7q21.3 guanine nucleotide binding protein (G protein), gamma 11
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrineadrenal gland    
    Reproductivefemale systemovary   
     male systemtestis  highly
     male systemprostate   
    Respiratorylung    
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Cyp51
    Homologene
    FAMILY
  • cytochrome P450 subfamily 51
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • lanosterol 14 alpha-demethylase, involved in cholesterol biosynthesis
  • responds to cholesterol feedback regulation through sterol regulatory element binding proteins (SREBF1)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    sterol biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • FOXO4 interacts with SREBF2 and HIF2A to modulate CYP51A1 promoter activity
  • cell & other
    REGULATION
    induced by cholesterol deprivation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS