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FLASH GENE

Symbol

CYP4F22

contributors: mct - updated : 07-04-2006

HGNC name	cytochrome P450, family 4, subfamily F, polypeptide 22
HGNC id	26820

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	LMLI3 lamellar ichthyosis 3
Location	19p12      Physical location : 15.619.335 - 15.663.127
Synonym name	cytochrome P450, family 2, subfamily E, polypeptide 2 homolog
Synonym symbol(s)	LI3, FLJ39501
EC.number	1.14.14.-

DNA

TYPE	functioning gene
STRUCTURE	43.00 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed CYP4F22 14 - 2620 61 531 - -

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         liver         Reproductive male system testis     highly Skin/Tegument skin         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a CYP motif

HOMOLOGY

intraspecies

homolog to the leukotriene B4-omega-hydroxylase (CYP4F2)

Homologene

FAMILY

cytochrome p450 family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	having monooxygenase activity
	catalyzing the 20-hydroxylation of trioxilin A3 from the 12(R)-lipoxygenase pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

LMLI3

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS