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FLASH GENE
Symbol CYP4F2 contributors: mct - updated : 07-06-2011
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 2
HGNC id 2645
Location 19p13.12      Physical location : 15.988.833 - 16.008.884
Synonym name
  • leukotriene B4 omega-hydroxylase
  • cytochrome P450, subfamily IVF, polypeptide 2
  • leukotriene-B(4) 20-monooxygenase 1
  • cytochrome P450-LTB-omega
    • Synonym symbol(s) CPF2, CYPIVF2
    EC.number 1.14.13.30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 20.05 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure several putative regulating elements
    MAPPING cloned Y linked N status confirmed
    regionally located located in the CYP4F cluster with CYP4F11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2360 - 520 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver   lowly Homo sapiens
    Urinarykidney   moderately Homo sapiens
    cell lineage
    cell lines hepatoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Cyp4f6 (73.46 pc)
    homolog to murine Cyp4f13 (73.03 pc)
    Homologene
    FAMILY
  • cytochrome P450 subfamily IVF
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • metabolizing eicosanoid mediators
  • leukotriene 134 omega-hydroxylase
  • catalysing the inactivation of leukotriene B4 (LTB4), a potent mediator of inflammation responsible for recruitment and activation of neutrophils
  • responsible for the omega-hydroxylation of phytanic acid
  • having an an important role in the resolution of inflammation (Hardwick 2008)
  • functions as a predominant LTB4 and arachidonate omega-hydroxylase in human liver (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    leukotriene metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coeliac disease
  • to myocardial infarction (MI)
    • Variant & Polymorphism SNP
  • for men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (Fu 2009)
  • an SNP explains the dose variance of the therapeutic warfarin (Takeuchi 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS