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FLASH GENE
Symbol CYP4F2 contributors: mct - updated : 07-06-2011
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 2
HGNC id 2645
Location 19p13.12      Physical location : 15.988.833 - 16.008.884
Synonym name
  • leukotriene B4 omega-hydroxylase
  • cytochrome P450, subfamily IVF, polypeptide 2
  • leukotriene-B(4) 20-monooxygenase 1
  • cytochrome P450-LTB-omega
  • Synonym symbol(s) CPF2, CYPIVF2
    EC.number 1.14.13.30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 20.05 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure several putative regulating elements
    MAPPING cloned Y linked N status confirmed
    Physical map
    BRD4 19p13.1 bromodomain containing 4 AKAP8 19p13.1-q12 a kinase (PRKA) anchor protein 8 NAKAP95 19p13.12-p13.11 a kinase (PRKA) anchor protein 8 WIZ 19p13.1 widely-interspaced zinc finger motifs FLJ21438 19p13.12 hypothetical protein FLJ21438 PGRP-L 19p13.12 peptidoglycan recognition protein L precursor FLJ39501 19p13.12 hypothetical protein FLJ39501 LOC390896 19 similar to Cytochrome P450 4F6 (CYPIVF6) LOC388513 19 similar to 60S ribosomal protein L23a CYP4F8 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F3 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F12 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 12 OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12) LOC284433 19p13.12 hypothetical gene supported by NM_013940 OR10H1 19p13.1 olfactory receptor, family 10, subfamily H, member 1 LOC388515 19 LOC388515 LOC339377 19p13.12 similar to 4930572L20Rik protein CYP4F2 19p13.1-p12 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F11 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 11 LOC126541 19p13.12 similar to Olfactory receptor 10H4 LOC126537 19p13.12 similar to cytochrome P-450 FLJ25328 19p13.12 hypothetical protein FLJ25328 TPM4 19p13.1 tropomyosin 4 MEL 19p13.1 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog HSH2 19p13.12 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog KIP3 DKFZP586O0120 AP1M1 19p13.2 adaptor-related protein complex 1, mu 1 subunit KLF2 19p13.13-p13.11 Kruppel-like factor 2 (lung) EPS15R 19p13.12 Kruppel-like factor 2 (lung)
    regionally located located in the CYP4F cluster with CYP4F11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 2360 - 520 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver   lowly Homo sapiens
    Urinarykidney   moderately Homo sapiens
    cell lineage
    cell lines hepatoma cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Cyp4f6 (73.46 pc)
    homolog to murine Cyp4f13 (73.03 pc)
    Homologene
    FAMILY
  • cytochrome P450 subfamily IVF
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • metabolizing eicosanoid mediators
  • leukotriene 134 omega-hydroxylase
  • catalysing the inactivation of leukotriene B4 (LTB4), a potent mediator of inflammation responsible for recruitment and activation of neutrophils
  • responsible for the omega-hydroxylation of phytanic acid
  • having an an important role in the resolution of inflammation (Hardwick 2008)
  • functions as a predominant LTB4 and arachidonate omega-hydroxylase in human liver (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    leukotriene metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coeliac disease
  • to myocardial infarction (MI)
  • Variant & Polymorphism SNP
  • for men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (Fu 2009)
  • an SNP explains the dose variance of the therapeutic warfarin (Takeuchi 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS