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FLASH GENE
Symbol CYP4F11 contributors: mct/npt - updated : 05-07-2010
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 11
HGNC id 13265
Location 19p13.12      Physical location : 16.023.179 - 16.045.676
Synonym name cytochrome P450, subfamily IVF, polypeptide 11
Synonym symbol(s) CYPIVF11
EC.number 1.14.14.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 22.50 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
BRD4 19p13.1 bromodomain containing 4 AKAP8 19p13.1-q12 a kinase (PRKA) anchor protein 8 NAKAP95 19p13.12-p13.11 a kinase (PRKA) anchor protein 8 WIZ 19p13.1 widely-interspaced zinc finger motifs FLJ21438 19p13.12 hypothetical protein FLJ21438 PGRP-L 19p13.12 peptidoglycan recognition protein L precursor FLJ39501 19p13.12 hypothetical protein FLJ39501 LOC390896 19 similar to Cytochrome P450 4F6 (CYPIVF6) LOC388513 19 similar to 60S ribosomal protein L23a CYP4F8 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F3 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F12 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 12 OR10H2 19p13.1 olfactory receptor, family 10, subfamily H, member 2 OR10H3 19p13.1 olfactory receptor, family 10, subfamily H, member 3 LOC388514 19 similar to Cytochrome P450 4F12 (CYPIVF12) LOC284433 19p13.12 hypothetical gene supported by NM_013940 OR10H1 19p13.1 olfactory receptor, family 10, subfamily H, member 1 LOC388515 19 LOC388515 LOC339377 19p13.12 similar to 4930572L20Rik protein CYP4F2 19p13.1-p12 cytochrome P450, family 4, subfamily F, polypeptide 2 CYP4F11 19p13.1 cytochrome P450, family 4, subfamily F, polypeptide 11 LOC126541 19p13.12 similar to Olfactory receptor 10H4 LOC126537 19p13.12 similar to cytochrome P-450 FLJ25328 19p13.12 hypothetical protein FLJ25328 TPM4 19p13.1 tropomyosin 4 MEL 19p13.1 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog HSH2 19p13.12 mel transforming oncogene (derived from cell line NK14)- RAB8 homolog KIP3 DKFZP586O0120 AP1M1 19p13.2 adaptor-related protein complex 1, mu 1 subunit KLF2 19p13.13-p13.11 Kruppel-like factor 2 (lung) EPS15R 19p13.12 Kruppel-like factor 2 (lung)
regionally located located 16kb upstream of CYP4F2, in a second cluster of CYPAF genes
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2973 - 524 - Dhar (2008)
12 - 3395 - 524 - Dhar (2008)
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
intraspecies homolog to CYP4F2,CYP4F3,CYP4F8
Homologene
FAMILY
  • cytochrome P450 subfamily IVF
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • metabolizing eicosanoid mediators
  • catalyzed omega-hydroxylation of 3-hydroxystearate (Dhar 2008)
  • exhibited low activity for some drug N-demethylation reactions but none for activation of several pro-carcinogens (Tang 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS