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FLASH GENE
Symbol CYP4B1 contributors: - updated : 09-12-2006
HGNC name cytochrome P450, family 4, subfamily B, polypeptide 1
HGNC id 2644
Location 1p34-p12      Physical location : 47.264.669 - 47.285.020
Synonym name microsomal monooxygenase
Synonym symbol(s) P-450HP
EC.number 1.14.14.1
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PIK3R3 1p34.1 phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma) LOC388627 1 LOC388627 TSPAN-1 1p34.1 tetraspan 1 FLJ20277 RAD54L 1p32 RAD54-like (S. cerevisiae) MUF1 1p34.1 RAD54-like (S. cerevisiae) UQCRH 1p34.1 ubiquinol-cytochrome c reductase hinge protein MGC22960 1p34 MGC22960 gene FAAH 1p35-p34 fatty acid amide hydrolase LOC391036 1 similar to vitamin D3 hydroxylase associated protein LOC388628 1 hypothetical gene supported by BC021746 OTX3 1p34.1 orthodenticle homolog 3 (Drosophila) FLJ32011 1p34.1 hypothetical protein FLJ32011 MKNK1 1p34.1 MAP kinase-interacting serine/threonine kinase 1 MOB3C ATPAF1 1p33-p32.3 ATP synthase mitochondrial F1 complex assembly factor 1 LOC374973 1p34.1 LOC374973 KIAA0494 1pter-p22.1 LOC374973 CYP4B1 1p34-p12 cytochrome P450, family 4, subfamily B, polypeptide 1 LOC388629 1 similar to cytochrome P450 4Z1 CYP4Z2P 1p34.1-p33 cytochrome P450 4Z2 pseudogene CYP4A11 1p36.1-p32.1 cytochrome P450, family 4, subfamily A, polypeptide 11 CYP4X1 1p33 likely ortholog of rat cytochrome P450 4X1 CYP4Z1 1p33 cytochrome P450 4Z1 LOC284541 1p33 similar to fatty acid omega-hydroxylase CYP4A11 MAP17 1p33 membrane-associated protein 17 TAL1 1p32 T-cell acute lymphocytic leukemia 1 SIL 1p33-p32 TAL1 (SCL) interrupting locus UMP-CMPK UMP-CMP kinase FOXE3 1p32 forkhead box E3 FOXD2 1p34-p32 forkhead box D2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Nervousnervecranial nerve  highly
Respiratorylung   highly
 respiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY multigenic cytochrome P450 superfamily of mixed-function monooxygenases
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • involved in an NADPH-dependent electron transport pathway
  • oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    fatty acids
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by various xenobiotics
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS