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FLASH GENE
Symbol CYP4B1 contributors: - updated : 09-12-2006
HGNC name cytochrome P450, family 4, subfamily B, polypeptide 1
HGNC id 2644
Location 1p34-p12      Physical location : 47.264.669 - 47.285.020
Synonym name microsomal monooxygenase
Synonym symbol(s) P-450HP
EC.number 1.14.14.1
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Nervousnervecranial nerve  highly
Respiratorylung   highly
 respiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
Homologene
FAMILY multigenic cytochrome P450 superfamily of mixed-function monooxygenases
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic,microsome
basic FUNCTION
  • involved in an NADPH-dependent electron transport pathway
  • oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    fatty acids
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by various xenobiotics
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS