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FLASH GENE
Symbol CYP4A11 contributors: mct - updated : 06-06-2007
HGNC name cytochrome P450, family 4, subfamily A, polypeptide 11
HGNC id 2642
Location 1p33      Physical location : 47.394.847 - 47.407.156
Synonym name
  • cytochrome P450, subfamily IVA, polypeptide 11
  • omega hydroxylasse, fatty acid
  • fatty acid omega-hydroxylase
  • lauric acid omega-hydroxylase
    • Synonym symbol(s) CYP4A2, CP4Y, CYP4AII
    EC.number 1.14.15.3
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     12 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   lowly
    Urinarykidney   lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to dog CYP4A11 (78.39 pc)
    homolog to rattus Cyp4a10 (77.56 pc)
    homolog to murine Cyp4a10 (77.56 pc)
    intraspecies homolog to CYP4A22
    Homologene
    FAMILY
  • cytochrome P450 subfamily IVA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylation of medium chain fatty acid such as laurate and myristate
  • responsible for the omega-hydroxylation of phytanic acid
  • involved in the balance of lipids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    repressed by retinoic acid in liver cells (suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS