SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,microsome
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| text
| anchored to the membrane via a single transmembrane domain, axon |
| basic FUNCTION
| cholesterol 24-hydroxylase, catalyzing the synthesis of 24S-hydroxycholesterol, an oxysterol that is readily secreted from the CNS into the plasma and to a lesser extent, into 25 hydroxycholesterol |
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play a role in the brain cholesterol homeostasis  |
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catalyzes cholesterol 24S-hydroxylation, the first step in cholesterol elimination from the brain |
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cholesterol 24-hydroxylase constitutes a major tissue-specific pathway for cholesterol turnover in the brain |
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components of the brain microsomal mixed-function monooxygenase system that catalyzes the conversion of cholesterol to 24-hydroxycholesterol |
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initiating the major pathway of cholesterol elimination from the brain and thereby controls cholesterol turnover in this organ, and complexing with four structurally distinct pharmaceuticals |
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neuron-specific cytochrome P450 that playing a pivotal role in maintaining cholesterol homeostasis in the CNS |
