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FLASH GENE
Symbol CYP3A5 contributors: mct - updated : 29-03-2008
HGNC name cytochrome P450, family 3, subfamily A, polypeptide 5
HGNC id 2638
Location 7q21.1      Physical location : 99.245.812 - 99.277.621
Genatlas name see CYP3A@
Synonym name
  • aryl hydrocarbon hydroxylase
  • cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
  • flavoprotein-linked monooxygenase
  • niphedipine oxidase
  • Synonym symbol(s) CP35, P450PCN3, PCN3
    EC.number 1.14.-.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem, component of a cluster
    STRUCTURE 31.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (CAAT box)
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389539 7 similar to importin alpha 1b ARPC1A 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1A, 41kDa ARPC1B 7q22.1-q31.33 actin related protein 2/3 complex, subunit 1B, 41kDa PDAP1 7q11.21 PDGFA associated protein 1 G10 7q11.21 PDGFA associated protein 1 CPSF4 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa KIAA0632 7q22.1 cleavage and polyadenylation specific factor 4, 30kDa ATP5J2 7q21.3-q22 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f, isoform 2 LOC285989 7q22.1 hypothetical protein LOC285989 ZNF394 7q22.1 zinc finger protein 394 ZFP95 7q22 zinc finger protein 95 homolog (mouse) DKFZp727G131 7q22.1 hypothetical protein DKFZp727G131 VIK 7q22.1 vav-1 interacting Kruppel-like protein ZNF498 7q22.1 zinc finger protein 498 CYP3A5 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5P1 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 1 CYP3A7 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 7 CYP3A5P2 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 CYP3A43 7q21.1 cytochrome P450, family 3, subfamily A, polypeptide 43 TRIM4 7q22-q31.1 tripartite motif-containing 4 AZGP1 7q22.1 alpha-2-glycoprotein 1, zinc LOC392078 7 hypothetical gene supported by BC022382 ZNF36 7q21.3-q22.1 zinc finger protein 36 (KOX 18) ZNF38 7q21-q22 zinc finger protein 38 ZNF3 7q22.1 zinc finger protein 3 (A8-51) COPS6 7q22.1 zinc finger protein 3 (A8-51)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1707 - 502 - Fanta (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   highly
     liver   highly
     stomach   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIIA
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • having an endogenous function related to the metabolism of intra-prostatic androgens and cell growth
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    drug including cyclosporine A ;metabolism of sex hormones
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by glucocorticoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility to prostate cancer
    Variant & Polymorphism other polymorphisms affecting CYP3A5 activity may result in altered prostate cancer risk and aggressiveness.
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS