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FLASH GENE
Symbol CYP3A43 contributors: - updated : 29-01-2004
HGNC name cytochrome P450, family 3, subfamily A, polypeptide 43
HGNC id 17450
Location 7q21.1      Physical location : 99.425.635 - 99.464.173
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 37.00 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2167 - 504 - Smith
- splicing 2164 - 503 - Smith
- splicing 2001 - 420 - Smith
lacking an internal exon
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrinepancreas   moderately
Reproductivemale systemtestis  moderately
 male systemprostate  highly
Urinarykidney   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text liver,skeletal muscle,kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer heteromer , monomer
HOMOLOGY
intraspecies homolog to CYP3A4,CYP3A5,CYP3A7
Homologene
FAMILY
  • cytochrome P450 subfamily
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,nucleus,nucleolus
    text microsomes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase POR
    cell & other
    REGULATION
    induced by rifampidin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS