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FLASH GENE
Symbol CYP39A1 contributors: npt - updated : 09-07-2002
HGNC name cytochrome P450, family 39, subfamily A, polypeptide 1
HGNC id 17449
Location 6p12.3      Physical location : 46.517.444 - 46.620.523
Synonym name
  • cytochrome P450 39A1
  • cytochrome P450, subfamily XXXIX (oxysterol 7 alpha-hydroxylase), polypeptide 1
  • EC.number 1.14.13.99
    DNA
    TYPE functioning gene
    STRUCTURE 103.07 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2288 54 469 - Nelson (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Cyp39a1
    Homologene
    FAMILY
  • cytochrome P450 family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • hydroxylating, preferentialy, 24-hydroxycholesterol
  • catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
  • endoplasmic reticulum protein which is involved in the conversion of cholesterol to bile acids
  • preferentially catalyzes the 7alpha-hydroxylation of 24-hydroxycholesterol and may play a role in the alternative bile acid synthesis pathway in the liver
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein flavoprotein P450 oxidoreductase POR
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS