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FLASH GENE
Symbol CYP2S1 contributors: - updated : 08-06-2007
HGNC name cytochrome P450, family 2, subfamily S, polypeptide 1
HGNC id 15654
Location 19q13.1      Physical location : 41.699.114 - 41.713.443
EC.number 1.14.14.1
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
NUMBL 19q13-q13.2 numb homolog (Drosophila)-like ADCK4 19q13.2 aarF domain containing kinase 4 ITPKC 19q13.1 inositol 1,4,5-trisphosphate 3-kinase C FLJ41131 19q13.2 FLJ41131 protein SNRPA 19q13.2 small nuclear ribonucleoprotein polypeptide A MIA 19q13.32-q13.33 melanoma inhibitory activity RAB4B 19q13.2 RAB4B, member RAS oncogene family EGLN2 19q13.2 egl nine homolog 2 (C. elegans) CYP2T2P 19q13.2 cytochrome P450, family 2, subfamily T, polypeptide 2 pseudogene CYP2F1P 19q13.2 cytochrome P450, family 2, subfamily F, polypeptide 1 pseudogene CYP2A6 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 6 CYP2A7 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 7 CYP2G1 19q13.2 cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene CYP2A7P1 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1 CYP2B7 19q13.2 cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene CYP2B6 19q13.2 cytochrome P450, family 2, subfamily B, polypeptide 6 CYP2G2 19pter-p13.3 cytochrome P450, family 2, subfamily G, polypeptide 2 CYP2A13 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 13 CYP2F1 19q13.2 cytochrome P450, family 2, subfamily F, polypeptide 1 CYP2T3P 19q13.32 cytochrome P450, family 2, subfamily T, polypeptide 3 pseudogene CYP2S1 19q13.1 cytochrome P450, family 2, subfamily S, polypeptide 1 AXL 19q13.1 AXL receptor tyrosine kinase E1B-AP5 19q13.31 E1B-55kDa-associated protein 5 MGC20255 19q13.31 hypothetical protein MGC20255 TGFB1 19q13.2 transforming growth factor, beta 1 (Camurati-Engelmann disease) MGC4093 19q13.31 hypothetical protein MGC4093 RRP46 19q13.1 exosome component Rrp46 BCKDHA 19q13.2 branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease) BGALT15 19q13.31 beta galactosyltransferase BGALT15 FLJ10241 19q13.31 hypothetical protein FLJ10241 LOC388543 19 LOC388543 LOC283855 19q13.31 similar to tropomyosin 3 PLEKHA3P1 19 pleckstrin homology domain-containing, family A member 3 pseudogene 1 R29124_1 19q13.31 hypothetical protein R29124_1 CEACAMP3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 intestinesmall intestine   
 intestinelarge intestinecolon moderately
 mouth   predominantly
 stomach   moderately
Lymphoid/Immunespleen    
Respiratorylung    
 respiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Cyp2s1 (74.3 pc)
homolog to murine Cyp2s1 (79 pc)
intraspecies homolog to CYP2
Homologene
FAMILY
  • cytochrome P450 subfamily IIS
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • acting as a monooxygenase
  • involved in the hydroxylation of xenobiotics
  • having a potential importance for extrahepatic xenobiotic metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
  • oxydative metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS