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FLASH GENE
Symbol CYP2J2 contributors: mct - updated : 22-02-2012
HGNC name cytochrome P450, family 2, subfamily J, polypeptide 2
HGNC id 2634
Location 1p32.1      Physical location : 60.358.980 - 60.392.423
Synonym name arachidonic acid epoxygenase,polypeptide 2
Synonym symbol(s) CPJ2
EC.number 1.14.14.1
DNA
TYPE functioning gene
STRUCTURE 33.44 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • c-Jun-responsive module between -122 and -50 in the CYP2J2 proximal promoter contains an atypical AP-1 element at -105/-95 that has a major role in c-Jun transactivation and acts in conjunction with the -56/-63 element to regulate expression
  • frequent promoter polymorphism of CYP2J2 decreases gene expression and is associated with coronary artery disease.
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1876 - 502 - 1998 9570962
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly Homo sapiens
    Digestiveintestine    
     liver   highly
     pharynx   highly
    Reproductivefemale systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningendothelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIJ
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • catalyzing the NADPH-dependent oxidation of arachidonic acid to form eicosanoids
  • lipid metabolising cytochrome P450, which produces anti-inflammatory mediators, and is considered the major epoxygenase in the human heart
  • may be an unrecognized participant in first-pass metabolism
  • converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid cancers
  • plays a key role in the pathogenesis of human hematologic malignant disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    text oxidative metabolism
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    fatty acids
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein
  • flavoprotein P450 oxidoreductase (POR)
  • PPARA interacting with CYP2J2 (activates the nuclear receptor PPARA)
  • cell & other
    REGULATION
    inhibited by c-Jun/c-Fos heterodimers promoted by hypoxia
    Other regulated by AP-1 in normoxia and hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    when human monocytes differentiated into macrophages and that human monocytic cells and macrophages have a pathway to metabolize arachidonic acid using CYP epoxygenases
    Susceptibility
  • to coronary artery disease
  • myocardial infarction (MI)
  • Variant & Polymorphism other
  • frequent promoter polymorphism associated with coronary artery disease
  • myocardial infarction (MI) is associated with the CC genotype of rs2271800 in the human CYP2J2 gene
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    inhibition of CYP2J2 may be a promising therapeutic strategy for hematologic malignant diseases
    ANIMAL & CELL MODELS