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FLASH GENE
Symbol CYP2F1 contributors: - updated : 12-07-2006
HGNC name cytochrome P450, family 2, subfamily F, polypeptide 1
HGNC id 2632
Location 19q13.2      Physical location : 41.620.352 - 41.634.281
Synonym symbol(s) CYP2F
EC.number 1.14.14.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • tightly linked to a full size LTR of human endogenous retroviruses HERV-K
  • clustered with five CYP2As, three CYP2B, and CYP2Fs genes
  • STRUCTURE 13.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • a lung specific factor in the promoter region
  • an untranslated exon 1
  • MAPPING cloned Y linked N status confirmed
    Physical map
    NUMBL 19q13-q13.2 numb homolog (Drosophila)-like ADCK4 19q13.2 aarF domain containing kinase 4 ITPKC 19q13.1 inositol 1,4,5-trisphosphate 3-kinase C FLJ41131 19q13.2 FLJ41131 protein SNRPA 19q13.2 small nuclear ribonucleoprotein polypeptide A MIA 19q13.32-q13.33 melanoma inhibitory activity RAB4B 19q13.2 RAB4B, member RAS oncogene family EGLN2 19q13.2 egl nine homolog 2 (C. elegans) CYP2T2P 19q13.2 cytochrome P450, family 2, subfamily T, polypeptide 2 pseudogene CYP2F1P 19q13.2 cytochrome P450, family 2, subfamily F, polypeptide 1 pseudogene CYP2A6 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 6 CYP2A7 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 7 CYP2G1 19q13.2 cytochrome P450, family 2, subfamily G, polypeptide 1 pseudogene CYP2A7P1 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1 CYP2B7 19q13.2 cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene CYP2B6 19q13.2 cytochrome P450, family 2, subfamily B, polypeptide 6 CYP2G2 19pter-p13.3 cytochrome P450, family 2, subfamily G, polypeptide 2 CYP2A13 19q13.2 cytochrome P450, family 2, subfamily A, polypeptide 13 CYP2F1 19q13.2 cytochrome P450, family 2, subfamily F, polypeptide 1 CYP2T3P 19q13.32 cytochrome P450, family 2, subfamily T, polypeptide 3 pseudogene CYP2S1 19q13.1 cytochrome P450, family 2, subfamily S, polypeptide 1 AXL 19q13.1 AXL receptor tyrosine kinase E1B-AP5 19q13.31 E1B-55kDa-associated protein 5 MGC20255 19q13.31 hypothetical protein MGC20255 TGFB1 19q13.2 transforming growth factor, beta 1 (Camurati-Engelmann disease) MGC4093 19q13.31 hypothetical protein MGC4093 RRP46 19q13.1 exosome component Rrp46 BCKDHA 19q13.2 branched chain keto acid dehydrogenase E1, alpha polypeptide (maple syrup urine disease) BGALT15 19q13.31 beta galactosyltransferase BGALT15 FLJ10241 19q13.31 hypothetical protein FLJ10241 LOC388543 19 LOC388543 LOC283855 19q13.31 similar to tropomyosin 3 PLEKHA3P1 19 pleckstrin homology domain-containing, family A member 3 pseudogene 1 R29124_1 19q13.31 hypothetical protein R29124_1 CEACAMP3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 3
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIF
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nucleus
    basic FUNCTION
  • monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
  • dehydrogenation of 3-methylindol an endogenous toxin derived from tryptophase, xenobiotics, ethocycoumarin and others
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS