SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,microsome
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| text
| mitochondrial CYP2E1 induces oxidative stress and augments alcohol-mediated cell/tissue injury  |
| basic FUNCTION
| involved in monooxygenation of both endogenous and exogenous substrates |
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metabolizes several precarcinogens, drugs, and solvents to reactive metabolites |
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involved in the metabolic activation of nitrosamines, oxygenation of alcohol, xenobiotics, carcinogens |
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generate reactive oxygen species (ROS), toxic molecules implicated in the pathogenesis of the disease, and CYP2E1 inhibition increases extracellular dopamine (DA) in the nervous system |
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capable of inducing significant ER protein damage and stress via its catalytic activation of pro-oxidants |
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involved in the biotransformation of xenobiotics and endogenous substrates |
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having ability to effectively bind and metabolize both small molecule substrates and fatty acids |
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major microsomal ethanol metabolizing enzyme interacting with genes, involved in detoxification of reactive oxygen species, such as glutathione-S-transferases M1 (GSTM1) and alcohol intake, gamma-aminobutyric acid receptor gamma2 (GABRG2) |
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play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of cancer |
