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FLASH GENE
Symbol CYP2D6 contributors: mct/npt - updated : 01-07-2008
HGNC name cytochrome P450, family 2, subfamily D, polypeptide 6
HGNC id 2625
Corresponding disease
CYP2D6DM drug metabolism, CYP2D6-related
Location 22q13.1      Physical location : 42.522.501 - 42.526.883
Synonym name
  • cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6
  • debrisoquine 4-hydroxylase
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • xenobiotic monooxygenase
  • Synonym symbol(s) RP4-669P10.2, CPD6, CYP2D, CYP2D@, CYP2DL1, MGC120389, MGC120390, P450-DB1, P450C2D
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.00 kb     9 Exon(s)
    text structure see CYP2@
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1673 - 497 - Halling (2008)
    - - 1520 55.7 446 - Halling (2008)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunespleen    
    Reproductivefemale systembreastmammary gland  
     male systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ER targeting domain
  • a proline-rich domain as well as the putative protein kinase A (PKA) and protein kinase C (PKC)-specific phosphorylation sites
  • conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IID
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    text mitochondrial in liver (Sangar 2010)
    basic FUNCTION
  • monooxygenase
  • metabolizing antiarrythmics (sparteine and propafenone), amitryptiline, debrisoquine, catalyzing the demethylation of 7 ethoxy-coumarin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    text oxidative metabolism
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CYP2D6DM
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    reduced CYP2D6 activity was a negative risk factor for methamphetamine dependence (Otani 2008)
    Susceptibility
  • to poor metabolizer phenotype (debrisoquine, sparteine)
  • to acute lymphoid and myeloid leukemia
  • Variant & Polymorphism other
  • certain alleles result in the poor metabolizer phenotype
  • "null" variants increasing the risk of acute lymphoid and myeloid leukemia
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS