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FLASH GENE
Symbol CYP2C8 contributors: - updated : 19-10-2005
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 8
HGNC id 2622
Location 10q23.33      Physical location : 96.796.529 - 96.829.254
Synonym name
  • flavoprotein-linked monooxygenase
  • mephenytoin 4-hydroxylase
  • microsomal monooxygenase
  • Synonym symbol(s) CPC8, P450 MP-12/MP-20
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 32.00 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked N status confirmed
    Map cen - CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray (95), Finta (00)
    RNA
    TRANSCRIPTS type messenger
    text several transcripts by intra and for intergenic splicing with other genes of the cluster
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     mouthtongue   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase involved in an NADPH-dependent electron transport pathway
  • hepatic drug-metabolizing enzymes that oxidizes therapeutic drugs such as taxol and cerivastatin and endobiotics such as retinoic acid and arachidonic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    NADPH, heme
    protein flavoprotein P450 oxidoreductase (POR)
    cell & other
    REGULATION
    induced by phenobarbital
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS