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FLASH GENE
Symbol CYP2C18 contributors: - updated : 05-06-2006
HGNC name cytochrome P450, family 2, subfamily C, polypeptide 18
HGNC id 2620
Location 10q24      Physical location : 96.443.250 - 96.495.945
Synonym symbol(s) CPCI, CYP2C, CYP2C17, P450IIC17, P450-6B/29C
EC.number 1.14.14.1
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • located within a cluster of cytochrome P450 genes on chromosome 10q24
  • STRUCTURE 52.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    MAPPING cloned N linked N status confirmed
    Map cen- CYP2C18 - CYP2C19 - CYP2C9 - CYP2C8 - qter
    Authors Gray et al (95)
    regionally located . located within a cluster of cytochrome P450 genes on chromosome 10q24
    RNA
    TRANSCRIPTS type messenger
    text several transcripts resulting from exon skipping (table), or from intergenic splicing wiht other members of the cluster
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - - - - Zaphiropoulos
    lacking exons 4, 5
    - - - - - - Zaphiropoulos
    lacking exons 4, 5, 6
    - - - - - - Zaphiropoulos
    lacking exons 4, 5, 7
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver   predominantly
     mouthtongue  highly
     pancreas exocrine   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to rattus Cyp2c37 (76.7pc)
    homolog to murine Cyp2c39 (74.2pc)
    homolog to chicken CYP2C18 (58.5pc)
    Homologene
    FAMILY
  • cytochrome P450 subfamily IIC
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • acting as a monooxygenase
  • hydroxylation of mephenytoin and other xenobiotics
  • involved in an NADPH-dependent electron transport pathway
  • oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug
    signaling
  • oxidative metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • Fe2+
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
  • O2
  • REGULATION
    induced by various foreign compounds, including drugs, pesticides, and carcinogens, to high levels in liver and other tissues
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS