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FLASH GENE
Symbol CYP2B6 contributors: SGE/npt - updated : 13-08-2009
HGNC name cytochrome P450, family 2, subfamily B, polypeptide 6
HGNC id 2615
Location 19q13.2      Physical location : 41.497.203 - 41.524.301
Synonym name
  • cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6
  • P450 IIB1
  • Synonym symbol(s) CPB6, IIB1, P450, CYPIIB6, CYP2B
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, gene in gene
    text
  • embedded in a CYP2A pseudogene (CYP2A7P1)
  • component of a cluster of CYP2A, CYP2B, CYP2F genes
  • STRUCTURE 27.10 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • CYP2B6 promoter is activated by CAR, HNF4A and ERG1 (Inoue 2009)
  • MAPPING cloned Y linked N status provisional
    regionally located in the middle of a CYP2A pseudogene (CYP2A7P1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3052 - 491 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     liver   highly
    Respiratorylung    
     respiratory tracttrachea   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 subfamily B
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenase
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase which catalyze many reactions involved in drug metabolism, synthesis of cholesterol, steroids and other lipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    oxidative metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with CYP2A6 (Ring 2007)
  • PGRMC1 binds to POR, which may influence CYP2B6 activity
  • PGRMC1 negatively modulates the drug-metabolizing activities of CYP2B6 through direct interaction
  • cell & other
    REGULATION
    induced by vitamin D receptor pathway
    phenobarbital and cyclophosphamide
    Other phosphorylation is accompanied by a decrease in enzyme activity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS