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FLASH GENE
Symbol CYP26A1 contributors: mct/shn - updated : 03-06-2013
HGNC name cytochrome P450, family 26, subfamily A, polypeptide 1
HGNC id 2603
Location 10q23.33      Physical location : 94.833.231 - 94.837.641
Synonym name
  • P450, retinoic acid-inactivating, 1
  • cytochrome P450, subfamily XXVIA, polypeptide 1
  • cytochrome P450 retinoic acid-inactivating 1
  • cytochrome P450RAI
  • retinoic acid-metabolizing cytochrome
  • retinoic acid 4-hydroxylase
  • Synonym symbol(s) CP26, P450RAI, CYP26, P450RAI1, RP11-348J12.1
    EC.number 1.14.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 4.41 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D10S583 - D10S1755 - CYP26A1 - D10S185 - D10S200 - qter
    Authors White (98)
    Text [CYP26A1 ]
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2119 56 497 - 1997 9228017
    7 splicing initiation site 2245 48 428 - 1997 9228017
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Homo sapiens
    endocrinebraindiencephalonpituitary  
    Reproductivefemale systemuterus    Homo sapiens
     male systemtestis   
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines HEK293, LC-T, SK-L6, MCF7, NB4, U937, HepG2 (
    fluid/secretion
    at STAGE
    physiological period embryo, fetal, pregnancy
    Text placenta, rostral neural, plate, tail bud
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to Cyp26a1, Mus musculus
    ortholog to Cyp26a1, Rattus norvegicus
    ortholog to cyp26a1, Danio rerio
    Homologene
    FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • may be essential in controlling retinoic acid levels during development (
  • all-trans-retinoic acid 4-hydroxylation and 18-hydroxylation in extrahepatic metabolism of retinoic acid
  • play a critical role in defining the normal anterior limit of the pancreatic field (
  • has a role in determining the cellular exposure to RA by inactivating RA in cells that do not need RA
  • retinoic acid (RA)-metabolizing enzyme, is involved in VA (Vitamin A) metabolism
  • uterine CYP26A1 activity is important for the maintenance of pregnancy, especially during the process of blastocyst implantation
  • playing a role in maintaining normal hindbrain patterning, vertebral identity and development of posterior structure
  • CYP26B1 and CYP26A1 are regulated by different nuclear receptors, resulting in tissue-specific expression patterns
  • catalyzes the oxidation of all-trans (at)-retinoic acid (RA), is induced moderately by RA in numerous tissues, but is highly responsive in liver
  • has high ligand selectivity but accepts structurally related nuclear receptor agonists as inhibitors
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport , detoxification
    text metabolism of 9-cis and all-trans isomers of retinoic acid (
    PATHWAY
    metabolism drug , vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • NR2F1 is involved in the regulatory modulation of the expression of at least two genes, CYP26A1 and HOXA1
  • interactions between CYP26A1 and CDX4 modulate RA levels along the anterior-posterior (AP) axis to segregate the posterior neural plate into the hindbrain and spinal cord territories
  • cell & other
    REGULATION
    induced by retinoic acid
    specifically induced in the uterus during implantation period and localized in the uterine luminal epithelium (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • nonsyndromic optic nerve aplasia (
  • Marker
    Therapy target
  • Cyp26a1(-/-) mice are phenotypically rescued by heterozygous disruption of Aldh1a2 (
  • ANIMAL & CELL MODELS
  • Cyp26a1(-/-) mouse fetuses have lethal morphogenetic phenotypes mimicking those generated by excess retinoic acid administration (
  • Disruption of Cyp26 function causes a dramatic expansion of pancreatic cell types toward the anterior of the zebrafish embryo (