Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CYP1B1 | contributors: mct - updated : 16-03-2011 |
HGNC name | cytochrome P450, family 1, subfamily B, polypeptide 1 |
HGNC id | 2597 |
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Corresponding disease |
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Location | 2p22.2 Physical location : 38.294.745 - 38.303.323 | ||||
Synonym name | |||||
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Synonym symbol(s) | CP1B | ||||
EC.number | 1.14.14.1 |
DNA |
TYPE | functioning gene |
STRUCTURE | 8.58 kb 3 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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text structure |
MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage | expressed in human nonpigmented ciliary epithelial cell line |
cell lines | NHEK |
fluid/secretion |
at STAGE |
physiological period | embryo, fetal |
Text | eye, trabecular meshwork, fetal thymus |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | HemoP |
mono polymer | monomer |
HOMOLOGY |
interspecies | ortholog to Cyp1b1, Mus musculus |
ortholog to Cyp1b1, Rattus norvegicus | |
ortholog to cyp1b1, Danio rerio |
Homologene |
FAMILY |
CATEGORY | enzyme , transport |
CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | development , electron transport , detoxification |
text | |
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PATHWAY |
metabolism | drug |
signaling | sensory transduction/vision |
a component |
INTERACTION |
DNA |
RNA |
small molecule | cofactor, nucleotide, |
protein | |
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cell & other |
REGULATION |
activated by | in retinal ganglion cells during development, | |
and overexpression of the gene increased | ||
survival of the cells |
induced by | dioxin | |
by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) |
Other | might be regulated by NR5A1 and CREB1 |
ASSOCIATED DISORDERS |
corresponding disease(s) | GLC3A , PTA2 |
related resource | Human Cytochrome P450 (CYP) Allele Nomenclature Committee |
Susceptibility |
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Variant & Polymorphism SNP , other | |
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Candidate gene | for Peters anomaly | |
Marker
Therapy target
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ANIMAL & CELL MODELS |