Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CYP1A2 | contributors: mct/npt - updated : 16-06-2010 |
HGNC name | cytochrome P450, family 1, subfamily A, polypeptide 2 |
HGNC id | 2596 |
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Location | 15q24.1 Physical location : 75.041.183 - 75.048.941 |
Genatlas name | see CYP1@ |
Synonym name | |
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Synonym symbol(s) | P3-450, CP12, CYPIA2, P450(PA), P450-P3 |
EC.number | 1.14.14.1 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | head to head |
text | located in a head-to-head orientation with CYP1A1, sharing a 5'-flanking region (Yoshinari 2010) |
STRUCTURE | 7.76 kb 7 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
text structure | a GC box, critical element for the CYP1A2 promoter ( promoter activity significantly dependent on the presence of the intact GC box) (Miyajima 209) |
MAPPING | cloned | Y | linked | N | status | provisional |
regionally located | separated from CYP1A1, 25kb away |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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conjugated | HemoP |
mono polymer | monomer |
HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | enzyme , transport |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS | electron transport |
PATHWAY |
metabolism | drug |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | cofactor, nucleotide, |
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protein |
cell & other |
REGULATION |
induced by | polyaromatic compound,dioxyn | |
by cruciferous (Peterson 2009) |
inhibited by | apiaceous vegetable intake (Peterson 2009) |
ASSOCIATED DISORDERS |
corresponding disease(s) |
related resource | Human Cytochrome P450 (CYP) Allele Nomenclature Committee |
Susceptibility |
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Variant & Polymorphism SNP | |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |