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FLASH GENE
Symbol CYP1A2 contributors: mct/npt - updated : 16-06-2010
HGNC name cytochrome P450, family 1, subfamily A, polypeptide 2
HGNC id 2596
Location 15q24.1      Physical location : 75.041.183 - 75.048.941
Genatlas name see CYP1@
Synonym name
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
  • dioxin-inducible P3-450
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • xenobiotic monooxygenase
  • aryl hydrocarbon hydroxylase
  • Synonym symbol(s) P3-450, CP12, CYPIA2, P450(PA), P450-P3
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text located in a head-to-head orientation with CYP1A1, sharing a 5'-flanking region (Yoshinari 2010)
    STRUCTURE 7.76 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure a GC box, critical element for the CYP1A2 promoter ( promoter activity significantly dependent on the presence of the intact GC box) (Miyajima 209)
    MAPPING cloned Y linked N status provisional
    Physical map
    B7H3 15q23-q24 B7 homolog 3 LOC388135 15 similar to RIKEN cDNA 6030419C18 gene MGC34741 15q22.33 hypothetical protein MGC34741 LOXL1 15q22 lysyl oxidase-like 1 STOML1 15q22 stomatin (EPB72)-like 1 PML 15q22 promyelocytic leukemia LOC390604 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC342096 15q22.33 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) KIAA1465 15q22.33 KIAA1465 protein ISLR 15q23-q24 immunoglobulin superfamily containing leucine-rich repeat FLJ12541 15q22.33 stimulated by retinoic acid gene 6 LOC338951 15q22.33 hypothetical LOC338951 FLJ32855 15q23 hypothetical protein FLJ32855 CYP11A1 15q23-q24 cytochrome P450, family 11, subfamily A, polypeptide 1 SEMA7A 15q22.3-q23 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A MGC14421 DRIL2 15q24 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A CLK3 15q24 CDC-like kinase 3 FLJ21128 15q23 hypothetical protein FLJ21128 CYP1A1 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 2 CSK 15q23-q25 c-src tyrosine kinase LMAN1L 15q22-23 lectin, mannose-binding, 1 like DKFZP434C131 15q23 DKFZP434C131 protein SCAMP2 15q23-q25 secretory carrier membrane protein 2 MPI 15q22-qter mannose phosphate isomerase FLJ00005 COX5A 15q25 cytochrome c oxidase subunit Va Rpp25 15q23 RNase P protein subunit p25 SCAMP5 15q22.33 RNase P protein subunit p25 MDS018 15q23 hypothetical protein MDS018 LOC390605 15 similar to stromal cell-derived factor 2 precursor DKFZP434H132 15q23 DKFZP434H132 protein LOC390606 15 similar to nucleolar phosphoprotein Nopp34 LOC388136 15 LOC388136 LOC388137 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC390607 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145801 15q23 similar to Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines) FLJ20452 15q23 hypothetical protein FLJ20452 NEIL1 15q23 nei endonuclease VIII-like 1 (E. coli) MAN2C1 15q11-q13 mannosidase, alpha, class 2C, member 1 SIN3A 15q24 SIN3 homolog A, transcriptional regulator (yeast) PTPN9 15q22.33 protein tyrosine phosphatase, non-receptor type 9 RNUT1 15q22.33 RNA, U transporter 1 C15orf12 15q24 chromosome 15 open reading frame 12 MGC32065 15q23 hypothetical protein MGC32065 CSPG4 15q23 chondroitin sulfate proteoglycan 4 (melanoma-associated)
    regionally located separated from CYP1A1, 25kb away
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3127 - 516 - Ikeya (1989)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase catalyzing polyaromatic hydrocarbons to potentially carcinogenic intermediates steroids, fatty acids, xenobiotics
  • biotransformation enzyme that activates several procarcinogens (Peterson 2009)
  • metabolizes a number of clinical drugs (clozapine, tacrine, tizanidine, and theophylline) (Zhou 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    induced by polyaromatic compound,dioxyn
    by cruciferous (Peterson 2009)
    inhibited by apiaceous vegetable intake (Peterson 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to PCT independent (porphyria congenita tarda )
  • to myocardial infarction
  • Variant & Polymorphism SNP
  • association of the highly inducible A/A genotype and susceptibility to PCT independent
  • association with common HFE alleles
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS