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FLASH GENE
Symbol CYP1A2 contributors: mct/npt - updated : 16-06-2010
HGNC name cytochrome P450, family 1, subfamily A, polypeptide 2
HGNC id 2596
Location 15q24.1      Physical location : 75.041.183 - 75.048.941
Genatlas name see CYP1@
Synonym name
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
  • dioxin-inducible P3-450
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • xenobiotic monooxygenase
  • aryl hydrocarbon hydroxylase
  • Synonym symbol(s) P3-450, CP12, CYPIA2, P450(PA), P450-P3
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text located in a head-to-head orientation with CYP1A1, sharing a 5'-flanking region (Yoshinari 2010)
    STRUCTURE 7.76 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure a GC box, critical element for the CYP1A2 promoter ( promoter activity significantly dependent on the presence of the intact GC box) (Miyajima 209)
    MAPPING cloned Y linked N status provisional
    regionally located separated from CYP1A1, 25kb away
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3127 - 516 - Ikeya (1989)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase catalyzing polyaromatic hydrocarbons to potentially carcinogenic intermediates steroids, fatty acids, xenobiotics
  • biotransformation enzyme that activates several procarcinogens (Peterson 2009)
  • metabolizes a number of clinical drugs (clozapine, tacrine, tizanidine, and theophylline) (Zhou 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • cell & other
    REGULATION
    induced by polyaromatic compound,dioxyn
    by cruciferous (Peterson 2009)
    inhibited by apiaceous vegetable intake (Peterson 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to PCT independent (porphyria congenita tarda )
  • to myocardial infarction
  • Variant & Polymorphism SNP
  • association of the highly inducible A/A genotype and susceptibility to PCT independent
  • association with common HFE alleles
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS