Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CYP1A1 contributors: mct/npt - updated : 12-01-2010
HGNC name cytochrome P450, family 1, subfamily A, polypeptide 1
HGNC id 2595
Location 15q24.2      Physical location : 75.011.883 - 75.017.877
Synonym name
  • arylhydrocarbone hydroxylase
  • P450 form 6
  • aryl hydrocarbon hydroxylase
  • cytochrome P1-450, dioxin-inducible
  • flavoprotein-linked monooxygenase
  • xenobiotic monooxygenase
  • cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
  • Synonym symbol(s) AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
    EC.number 1.14.14.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text located in a head-to-head orientation with CYP1A2, sharing a 5'-flanking region (Yoshinari 2010)
    STRUCTURE 6.00 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure
  • a BTR site in the promoter region
  • an ER8 motif, identified as an NR1I3-responsive element is highly conserved in the CYP1A1 proximal promoter sequences of various species, suggesting a fundamental role of NR1I3 in the xenobiotic-induced expression of CYP1A1 and CYP1A2 independent of aryl hydrocarbon receptor (Yoshinari 2010)
  • MAPPING cloned Y linked N status confirmed
    regionally located separated from CYP1A2, 25kb away
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2608 - 512 - Nelson 2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   moderately
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland moderately
     male systemprostate  highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to rattus Cyp1a1
    ortholog to murine Cyp1a1
    ortholog to zebrafish cyp1a1
    homolog to Drosophila Cyp18a1
    Homologene
    FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • monooxygenase catalyzing polyaromatic hydrocarbons to potentilally carcinogenic intermediates steroids, fatty acids, xenobiotics
  • oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    text NADPH-dependent electron transport pathway
    PATHWAY
    metabolism drug
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
  • heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • HDAC1 binding maintains the CYP1A1 gene in a silenced state in uninduced cells (Schnekenburger 2007)
  • cell & other
    REGULATION
    induced by polycyclic aromatic hydrocarbons
    2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    the AHR/ARNT (induction associated with modification of specific chromatin marks, including hyperacetylation of histone H3K14 and H4K16, trimethylation of histone H3K4, and phosphorylation of H3S10) (Schnekenburger 2007)
    repressed by BTEB1,KLF13,KLF16 via the BTE site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource Human Cytochrome P450 (CYP) Allele Nomenclature Committee
    Susceptibility
  • to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia
  • to osteoporosis
  • to risk of breast cancer for pre-menopausal women regardless of ethnicity
  • to hypospadias
  • to head and neck cancer
  • to obstructive pulmonary disease
  • Variant & Polymorphism other
  • codeleted with GSTM1 in susceptibility to lung sqamous cell carcinoma and to chilhood acute lymphoblastic leukemia
  • C4887A polymorphism may represent a possible genetic risk factor for osteoporosis
  • 462Val:3860G were significantly over-represented in chronic obstructive pulmonary disease (Vibhuti 2010)
  • polymorphism significantly associated with head and neck cancer risk (Singh 2009)
  • Msp1 variant in mother associated with a decreased risk for hypospadias
  • G2455G might reduce the risk of breast cancer for pre-menopausal women regardless of ethnicity
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS