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FLASH GENE

Symbol

CYP1A1

contributors: mct/npt - updated : 12-01-2010

HGNC name	cytochrome P450, family 1, subfamily A, polypeptide 1
HGNC id	2595

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24.2      Physical location : 75.011.883 - 75.017.877
Synonym name	arylhydrocarbone hydroxylase
	P450 form 6
	aryl hydrocarbon hydroxylase
	cytochrome P1-450, dioxin-inducible
	flavoprotein-linked monooxygenase
	xenobiotic monooxygenase
	cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
Synonym symbol(s)	AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
EC.number	1.14.14.1

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
text	located in a head-to-head orientation with CYP1A2, sharing a 5'-flanking region (Yoshinari 2010)
STRUCTURE	6.00 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
text structure	a BTR site in the promoter region
	an ER8 motif, identified as an NR1I3-responsive element is highly conserved in the CYP1A1 proximal promoter sequences of various species, suggesting a fundamental role of NR1I3 in the xenobiotic-induced expression of CYP1A1 and CYP1A2 independent of aryl hydrocarbon receptor (Yoshinari 2010)

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

separated from CYP1A2, 25kb away

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000499 7 - 2608 NP_000490 - 512 - Nelson 2004)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       moderately Reproductive female system uterus cervix   highly   female system breast mammary gland   moderately   male system prostate     highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

HemoP

mono polymer

monomer

HOMOLOGY

interspecies	ortholog to rattus Cyp1a1
	ortholog to murine Cyp1a1
	ortholog to zebrafish cyp1a1
	homolog to Drosophila Cyp18a1

Homologene

FAMILY	cytochrome P450 family
	multigenic cytochrome P450 superfamily of mixed-function monooxygenases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	monooxygenase catalyzing polyaromatic hydrocarbons to potentilally carcinogenic intermediates steroids, fatty acids, xenobiotics
	oxidizing a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

text	NADPH-dependent electron transport pathway

PATHWAY

metabolism

drug

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH
	heme

protein	flavoprotein P450 oxidoreductase (POR)
	HDAC1 binding maintains the CYP1A1 gene in a silenced state in uninduced cells (Schnekenburger 2007)

cell & other

REGULATION

induced by	polycyclic aromatic hydrocarbons
		2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
		the AHR/ARNT (induction associated with modification of specific chromatin marks, including hyperacetylation of histone H3K14 and H4K16, trimethylation of histone H3K4, and phosphorylation of H3S10) (Schnekenburger 2007)

repressed by

BTEB1,KLF13,KLF16 via the BTE site

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

Human Cytochrome P450 (CYP) Allele Nomenclature Committee

Susceptibility

to lung squamous cell carcinoma and to childhood acute lymphoblastic leukemia to osteoporosis to risk of breast cancer for pre-menopausal women regardless of ethnicity to hypospadias to head and neck cancer to obstructive pulmonary disease

Variant & Polymorphism other	codeleted with GSTM1 in susceptibility to lung sqamous cell carcinoma and to chilhood acute lymphoblastic leukemia
	C4887A polymorphism may represent a possible genetic risk factor for osteoporosis
	462Val:3860G were significantly over-represented in chronic obstructive pulmonary disease (Vibhuti 2010)
	polymorphism significantly associated with head and neck cancer risk (Singh 2009)
	Msp1 variant in mother associated with a decreased risk for hypospadias
	G2455G might reduce the risk of breast cancer for pre-menopausal women regardless of ethnicity

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS