Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CYCS contributors: mct/npt - updated : 23-05-2008
HGNC name cytochrome c, somatic
HGNC id 19986
Corresponding disease
THC4 thrombocytopenia 4, familial
Location 7p15.2      Physical location : 25.158.270 - 25.164.980
Synonym symbol(s) HCS, CYC
DNA
TYPE functioning gene
STRUCTURE 6.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CYP3A4 7q21.3-q22.1 cytochrome P450, family 3, subfamily A, polypeptide 4 LOC392873 7 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) C7orf9 7p21-p15 chromosome 7 open reading frame 9 CYP3A43 7q21.1 cytochrome P450, family 3, subfamily A, polypeptide 43 LOC392958 7 similar to Olfactory receptor 2AE1 TRIM4 7q22-q31.1 tripartite motif-containing 4 GJE1 7q22.1 gap junction protein, epsilon 1, 29kDa AZGP1 7q22.1 alpha-2-glycoprotein 1, zinc LOC392959 7 hypothetical gene supported by BC022382 LOC392756 7 similar to ZNF36 protein CYCS 7p21.2 cytochrome c, somatic ZNF38 7q21-q22 zinc finger protein 38 C7orf31 7p15.2 chromosome 7 open reading frame 31 ZNF3 7q22.1 zinc finger protein 3 (A8-51) COPS6 7q22.1 zinc finger protein 3 (A8-51) MCM7 7q21.3-q22.1 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) AP4M1 7q22.1 adaptor-related protein complex 4, mu 1 subunit LOC392005 7 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) TAF6 7q11 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa MGC40499 7q22.1 hypothetical protein MGC40499 LOC392757 7 similar to hypothetical protein MGC49416 LOC392960 7 similar to ribosomal protein L7 C7orf9 7p21-p15 chromosome 7 open reading frame 9 LOC392758 7 similar to CG14977-PA FLJ10925 7q22.1 hypothetical protein FLJ10925 GAL3ST-4 7q22 hypothetical protein FLJ10925 GPC2 7q22.1 glypican 2 (cerebroglycan) STAG3 7q22 stromal antigen 3 GATS 7q22.1 opposite strand transcription unit to STAG3 LOC392759 7 similar to stromal antigen 3 LOC392961 7 similar to opposite strand transcription unit to Stag3; Gats protein LOC392645 7 LOC392645 PILRB 7q22.1 paired immunoglobin-like type 2 receptor beta
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 5518 11 105 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Nervousbrain    
Reproductivemale systemtestis   
Skin/Tegumentskin    
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscular    
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytochrome c class I motif
  • conjugated HemoP
    HOMOLOGY
    interspecies ortholog to murine Cycs
    ortholog to rattus cycs
    intraspecies paralog to CYCSP45, CYCSP3, CYCSP7, CYCSP39, CYCSP512
    Homologene
    FAMILY
  • cytochrome c family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • accepts electrons from cytochrome b and transfers them to cytochrome oxidase
  • involved in initiation of nuclear apoptosis via its release to the cytoplasm
  • multifunctional protein with roles in electron transport, antioxidant defenses and apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe3+
  • protein
  • binding to APAF1 and leading to apoptosis (mediates apoptosis by interacting with monomeric APAF1, triggering a conformational change that enables apoptosome formation and caspase activation)
  • binding to IPTR1 during apoptosis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THC4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine embryonic stem cells with a targeted disruption of the cytochrome c gene died in utero and cells lacking cytochrome c are resistant to the proapoptotic effects of UV irradiation (Li et al. 2000)