| basic FUNCTION
| oxygen dependent mechanism of phagocytosis |
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reduction of oxygen to O-2 at the expense of NADPH, the O2-generated is the precursor of potent oxidants used to kill the invading microorganisms |
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critical for the bactericidal activity of phagocytic cells and plays a major role in innate immunity ( |
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its activity participates in the regulation of the phagosomal and endosomal pH in dendritic cells, and is required for efficient antigen cross-presentation ( |
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with NOX4 mediate proliferative response in endothelial cells ( |
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plays a fundamental role in host defense and innate immunity ( |
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plays a fundamental role in conferring macrophages with the ability to respond to extracellular ATP stimulation with robust changes in cellular oxidation |
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plays an important role in the control of afferent arteriole tone and is involved in the contractile responses to ANGPT2 and/or adenosine |
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plays a key role in apoptosis and phagocytosis of hepatocytes inducing activation of hepatic stellate cells and initiation of fibrosis in liver |
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role in the activation of autophagy, a cellular degradative pathway |
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mediating proliferative response in endothelial cells |
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reactive oxygen species generated by NADPH oxidase 2 and 4 (CYBB and NOX4)are required for chondrogenic differentiation |
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implicated as a source of rapid stretch-dependent ROS production at the junctional sarcoplasmic reticulum of cardiomyocytes (X-ROS signaling) |
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plays a role in neuronal cell death during retinal ischemia |
