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FLASH GENE
Symbol CYB5R2 contributors: - updated : 25-07-2005
HGNC name cytochrome b5 reductase 2
HGNC id 24376
Location 11p15.4      Physical location : 7.686.326 - 7.694.821
Synonym symbol(s) B5R.2
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
PCDH16 11p15.4 protocadherin 16 dachsous-like (Drosophila) MRPL17 11p15.5-p15.4 mitochondrial ribosomal protein L17 LOC387751 11 similar to very large inducible GTPase-1 LOC338755 11p15.4 similar to Olfactory receptor 2AG1 (HT3) LOC144125 11p15.4 similar to Olfactory receptor 2AG1 (HT3) OR6A1 11p15.5 olfactory receptor, family 6, subfamily A, member 1 JCG6 11p15.4 olfactory receptor-like protein JCG6 LOC341276 11p15.4 similar to hP4 olfactory receptor LOC283297 11p15.4 similar to Olfactory receptor 10A4 (HP2) (Olfactory receptor-like protein JCG5) LOC120776 11p15.4 similar to seven transmembrane helix receptor OR10A4P 11 olfactory receptor, family 10, subfamily A, member 4 pseudogene LOC120775 11p15.4 similar to Olfactory receptor 2D3 ZNF215 11p15.4 zinc finger protein 215 ZNF214 11p15.4 zinc finger protein 214 NALP14 11p15.4 NACHT, leucine rich repeat and PYD containing 14 HNRNPG-T 11p15 testes-specific heterogenous nuclear ribonucleoprotein G-T LOC143425 11p15.4 similar to synaptotagmin V UNQ564 11p15.4 MVAL564 PPFIBP2 11p15.5 PTPRF interacting protein, binding protein 2 (liprin beta 2) CYB5R2 11p15.4 cytochrome b5 reductase b5R.2 OVTN 11p15.4 oviductin protease LOC390091 11 similar to seven transmembrane helix receptor LOC390092 11 similar to olfactory receptor MOR204-2 LOC341278 11p15.4 similar to seven transmembrane helix receptor JCG3 11p15.4 olfactory receptor-like protein JCG3 JCG1 11p15.4 olfactory receptor-like protein JCG1 OR5E1P 11p15.5 olfactory receptor, family 5, subfamily E, member 1 pseudogene LOC390093 11 similar to Olfactory receptor 10A6 OR10A3 11p15.4 olfactory receptor, family 10, subfamily A, member 3 NALP10 11p15.4 NACHT, leucine rich repeat and PYD containing 10 EIF3S5 2p16.1 eukaryotic translation initiation factor 3, subunit 5 epsilon, 47kDa TUB 11p15.4 tubby homolog (mouse) RIC3 11p15.4 RIC3 protein LMO1 11p15.3 LIM domain only 1 (rhombotin 1) STK33 11p15.3 serine/threonine kinase 33
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 1341 31 276 - Baker
- splicing 1454 27 237 - Stausberg
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Nervousbrain   moderately
Reproductivemale systemtestis  predominantly
Respiratorylung   moderately
 respiratory tractlarynx  moderately
Skin/Tegumentskin   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two FAD-binding motifs
  • three NADPH-binding motifs
  • binding motifs for heme
  • HOMOLOGY
    interspecies ortholog to chicken CYB5R
    Homologene
    FAMILY
    CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and in erythrocyte, methemoglobin reduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide, other,
  • FAD
  • NADPH
  • heme
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS