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FLASH GENE
Symbol CYB561 contributors: - updated : 29-12-2005
HGNC name cytochrome b-561
HGNC id 2571
Location 17q11-qter      Physical location : 61.509.665 - 61.523.722
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
Binding site   transcription factor
MAPPING cloned Y linked   status provisional
Physical map
DKFZP564D166 17q24.1 putative ankyrin-repeat containing protein CYB561 17q11-qter cytochrome b-561 LOC342541 17q24.1 similar to peptidyl-Pro cis trans isomerase ACE 17q23 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 KCNH6 17q24.2 potassium voltage-gated channel, subfamily H (eag-related), member 6 HAN11 17q24.2 WD-repeat protein LOC51204 17q24.2 clone HQ0477 PRO0477p LOC390806 17 similar to Hypothetical protein FLJ14668 MAP3K3 17q24.2 mitogen-activated protein kinase kinase kinase 3 MGC10986 17q24.2 hypothetical protein MGC10986 LYK5 17q24.2 protein kinase LYK5 GK001 17q24.2 GK001 protein DDX42 17q24.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 FTSJ3 17q23 FtsJ homolog 3 (E. coli) PSMC5 17q24-q25 proteasome (prosome, macropain) 26S subunit, ATPase, 5 SMARCD2 17q23-q24 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 LOC388410 17 LOC388410 CSH2 17q23.3-q24.2 chorionic somatomammotropin hormone 2 GH2 17q23 growth hormone 2 CSH1 17q23.3-q24.2 chorionic somatomammotropin hormone 1 (placental lactogen)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal glandmedulla   
endocrinebraindiencephalonpituitary  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Lymphoid    
Nervousautonomous   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five transmembrane segments (5TM)
  • two heme binding centers
  • conjugated HemoP
    HOMOLOGY
    interspecies homolog to SDR2 murine stroma cell derived receptor 2
    homolog to Dcytb murine iron regulated genic reductase
    homolog to Cyb561 murine cytochrome b561
    homolog to Cyb561 bovine cytochrome b561
    intraspecies homolog to Dcytb duodenal cytochrome b
    homolog to SDR2 stroma cell derived receptor 2
    paralog to human chromosome 11q12.3
    Homologene
    FAMILY cytochrome family
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    text in the membrane of small synaptic vesicles and chromaffin granules
    basic FUNCTION
  • transmembrane iron channel, playing a putative role in ascorbate regeneration and Fe(III) reduction coupled to dopamine beta hydroxilase activity
  • playing a role in neurodegenerative disorders
  • specific to catecholamine and neuropeptide secretory vesicles of neuroendocrine tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS