| protein
| ligand of CXCL12 (to transduce CXCL12 -mediated chemotaxis) |
|
interaction between CXCR4 and CCR5 to exert specific biological functions and modulate T lymphocyte responses, and cooperation between receptors represents one key strategy for the functional plasticity of chemokines |
|
SYT3 is essential for CXCR4 recycling in T cells and thereby for the maintenance of high CXCR4 surface levels required for migration)  |
|
interact with PLEC (PLEC plays an important role in CXCR4 signaling and trafficking and HIV-1 infection) |
|
interacting with MIF and CD74 (CD74 forms functional complexes with CXCR4 that mediate MIF-specific signaling) |
|
molecular link between UBE2I and the metastasis genes such as CDC42 and CXCR4, and thus provide new insight into the mechanism by which UBE2I9 promotes tumor invasion and metastasis |
|
CCL18 is an important modulator of CXCR4-dependent responses in pre-B ALL cells via interactions with GPR30 (PMIDS: |
|
both ACKR3 and CXCR4 are important for endothelial progenitor cells (EPCs) in response to CXCL12 |
|
ACKR3 may interact with CXCR4 at the intracellular level, possibly affecting CXCR4 trafficking and/or coupling to other proteins |
|
PLG regulates MMP9-dependent CXCR4 expression to facilitate hematopoietic progenitor and stem cell (HPSC) mobilization in response to CSF3 |
|
coordinated changes in CXCR4 and S1PR5 responsiveness govern NK-cell trafficking |
|
HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 |
|
KLF11 regulates the expression of CXCR4 at a specific KLF11 binding site |
|
CXCL12 protects neural progenitor cells (hNPCs) from apoptotic challenges through CXCR7- and CXCR4-mediated endocytotic signaling |
|
NOTCH1 signaling regulates CXCR4 expression and the migration of mesenchymal stem cells |
|
DEFB103B can both antagonize CXCR4 function on T cells and promote receptor internalization in the absence of activation |
|
CXCL14 represents, along with CXCR7, molecules that co-evolved with the CXCL12-CXCR4 axis to modulate important physiological processes in development, stem cell maintenance, and immune responses |
|
ACKR3 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells |
|
MIF promotes the migration of B cells through a ZAP70-dependent pathway mediated by cooperative engagement of CXCR4 and CD74 |
|
novel role for the really interesting new gene-domain E3 ubiquitin ligase deltex-3-like (DTX3L) in regulating CXCR4 sorting from endosomes to lysosomes |
|
addition of CXCL12 leads to the dissociation of EIF2S2 from CXCR4 suggesting that stimulation of the receptor may trigger the local protein synthesis required for efficient cell movement |
|
RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs |
|
GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling |
|
link between the ECM protein MATN4 and cytokine receptor CXCR4 involved in the regulation of hematopoietic stem cells (HSCs) proliferation and expansion under acute stress |
|
ARRB1 and STAM cooperate to promote focal adhesion kinase autophosphorylation and chemotaxis via the chemokine receptor CXCR4 |
|
NRF1 regulates likely the expression of CXCR4 in normal retinal development and in pathologic processes of retinal hypoxia and neovascularization |
|
HCLS1 is important for the activation of GTPases and integrins, and mediates signaling downstream of many receptors including BCR, TCR, and CXCR4 |
|
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in breast cancer cells, malignant breast tumor and metastases | | tumoral
|
|
| --over
|
| |
in metastatic renal clear cell carcinoma | | constitutional
|
|
| --other
|
| |
aberrantly expressed in pathological specimens of vitreoretinal membranes | | tumoral
|
|
| --over
|
| |
in melanoma cells in primary lesions, significantly associated with the presence of ulceration, increased tumor thickness, a greater risk of developing regional and distant metastases and a higher mortality rate | | constitutional
|
|
|
| loss of function
| |
enhances osteoclastogenesis, and may enhance established skeletal tumor burden by increasing osteoclasts activity | | constitutional
|
|
| --over
|
| |
with CXCL12 in patients with heart failure | | constitutional
|
|
|
| gain of function
| |
CXCR4 activation, by promoting the differentiation of oligodendrocyte precursor cells into oligodendrocytes, is critical for remyelination of the injured adult CNS | | tumoral
|
|
| --over
|
| |
significantly associated with lymph node status and distant metastasis and indicated poor overall and disease free survival | |
